Learning and recognition of tactile temporal sequences by mice and humans
Learning and recognition of tactile temporal sequences by mice and humans
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DOI：
10.7554/elife.27333
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发表时间：
2017-08-16
期刊：
影响因子：
7.7
通讯作者：
Maravall, Miguel
中科院分区：
文献类型：
--
作者：
Bale, Michael R.;Bitzidou, Malamati;Maravall, Miguel
我们周围的世界充满了随着时间的推移而展开的刺激。当我们听到像音乐或演讲这样的听觉流，或者用指尖扫描一个纹理时，刺激中的物理特征会以特定的顺序串联起来。这种时间模式对于解释刺激至关重要。为了探索小鼠和人类学习触觉序列的能力，我们开发了一项任务，在这项任务中，受试者必须识别传递到胡须或指尖的连续调制噪声序列，该序列由其数百毫秒的时间模式定义。GO和NO-GO序列的不同之处在于其组成噪声调制段的顺序被暂时打乱。老鼠和人类都能有效地学习触觉序列。鼠标序列识别依赖于检测噪声幅度的变化；动物可以根据最早的信息做出决定。人类似乎使用了额外的线索，包括噪声调制段的持续时间。
The world around us is replete with stimuli that unfold over time. When we hear an auditory stream like music or speech or scan a texture with our fingertip, physical features in the stimulus are concatenated in a particular order. This temporal patterning is critical to interpreting the stimulus. To explore the capacity of mice and humans to learn tactile sequences, we developed a task in which subjects had to recognise a continuous modulated noise sequence delivered to whiskers or fingertips, defined by its temporal patterning over hundreds of milliseconds. GO and NO-GO sequences differed only in that the order of their constituent noise modulation segments was temporally scrambled. Both mice and humans efficiently learned tactile sequences. Mouse sequence recognition depended on detecting transitions in noise amplitude; animals could base their decision on the earliest information available. Humans appeared to use additional cues, including the duration of noise modulation segments.