Functional differences between macaque prefrontal cortex and caudate nucleus during eye movements with and without reward
Functional differences between macaque prefrontal cortex and caudate nucleus during eye movements with and without reward
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DOI：
10.1007/s00221-006-0622-4
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发表时间：
2007-01-01
影响因子：
2
通讯作者：
Hikosaka, Okihide
中科院分区：
文献类型：
--
作者：
Kobayashi, Shunsuke;Kawagoe, Reiko;Hikosaka, Okihide
前额叶皮层和基底神经节形成相互连接的网络，被认为在指导目标导向的行为中共同发挥重要作用。然而，这些结构似乎也有独立的运动输出途径，表明对目标导向行为的不同贡献。我们假设前额叶皮层将行为导向外部需求所要求的方向，基底神经节将行为导向内部动机的方向。为了验证这一假设，我们使用了一项任务，要求猴子在视觉线索指示的方向上进行记忆引导的扫视，而只有一个方向与奖励有关。我们观察到通常代表提示方向的外侧前额皮质（LPFC）和通常代表奖励相关方向的尾状核（CD）之间存在功能分离。此外，线索导向信号和奖励导向信号在两个区域的整合是不同的；当提示方向与奖励方向相反时，LPFC神经元保持对提示方向的调谐，而CD神经元则失去对提示方向的调谐。这两个脑区不同类型的空间调节可能导致不同类型的目标导向行为。
The prefrontal cortex and the basal ganglia form mutually connected networks and are thought to play essential roles together in guiding goal-directed behaviors. Yet, these structures seem to have independent pathways to motor outputs as well, suggesting differential contributions to goal-directed behaviors. We hypothesized that the prefrontal cortex guides actions to a direction required by external demands and the basal ganglia guide actions to an internally motivated direction. To test this hypothesis, we used a task in which monkeys were required to make a memory-guided saccade to a direction indicated by a visual cue while only one direction was associated with reward. We observed a functional dissociation between the lateral prefrontal cortex (LPFC), which commonly represented the cue direction, and the caudate nucleus (CD), which commonly represented the reward-associated direction. Furthermore, cue-directed and reward-directed signals were integrated differently in the two areas; when the cue direction and the reward direction were opposite, LPFC neurons maintained tuning to the cue direction, whereas CD neurons lost the tuning. Different types of spatial tuning in the two brain areas may contribute to different types of goal-directed behavior.