Diffusing capacity, membrane diffusing capacity, capillary blood volume, pulmonary tissue volume, and cardiac output measured by a rebreathing technique.
Diffusing capacity, membrane diffusing capacity, capillary blood volume, pulmonary tissue volume, and cardiac output measured by a rebreathing technique.
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通过再呼吸技术测量的弥散能力、膜弥散能力、毛细血管血容量、肺组织体积和心输出量。
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发表时间：
2015
期刊：
影响因子：
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通讯作者：
N. Atkins
中科院分区：
文献类型：
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作者：
M. Sackner;D. Greeneltch;M. Heiman;S. Epstein;N. Atkins
一种用于估计弥散能力、膜弥散能力、肺毛细血管血容量、肺毛细血管血流量和肺组织体积的再呼吸方法，包括在用质谱仪连续采样乙炔、（18 O）-一氧化碳、氧气和氦气的同时，再呼吸到袋中15秒。由于一氧化碳和氮气的质量在28时几乎相同，因此需要使用稳定的同位素C18 O来用质谱仪区分这种气体。在麻醉犬中，通过再呼吸技术与同时获得的指示剂稀释测量的肺毛细血管血流量的比较显示出良好的一致性。肺组织体积的估计似乎是相当可重复的和一致的，值往往是有点小，比其他研究者报告的正常受试者之间的变量较少。减去毛细血管血容量后，组织体积在休息时为311 ± 73 ml，在75瓦的运动时显著增加到352 ± 61 ml。使用再呼吸法的犬肺组织体积平均为9.2 ml/kg体重，这一平均值与先前报告的使用乙醚体积描记法的估计值相当。肺毛细血管血流量（正常受试者的心输出量）的斜率作为正常受试者运动期间耗氧量的函数，为耗氧量（毫升/分钟）的0.0060倍，与发表的值相同。重复呼吸技术为肺血流动力学参数的估计提供了一种快速、可靠、无创的方法。
A rebreathing method for estimating diffusing capacity, membrane diffusing capacity, pulmonary capillary blood volume, pulmonary capillary blood flow, and pulmonary tissue volume consists of rebreathing into a bag for 15 sec while acetylene, (18O)-carbon monoxide, oxygen, and helium are continuously sampled by a mass spectrometer. Because the masses of carbon monoxide and nitrogen are nearly identical at 28, it was necessary to use a stable isotope, C18O, to distinguish this gas with the mass spectrometer. Comparison of the pulmonary capillary blood flow by the rebreathing technique with the simultaneously obtained indicator dilution measurement in anesthetized dogs revealed good agreement. Estimations of pulmonary tissue volume appeared to be quite reproducible and consistent; the values tended to be somewhat smaller and less variable among normal subjects than reported by other investigators. After subtraction of capillary blood volume, tissue volume was 311 plus or minus 73 ml at rest and increased significantly to 352 plus or minus 61 ml at 75 watts of exercise. Pulmonary tissue volume in dogs using the rebreathing method averaged 9.2 ml per kg of body weight, a mean comparable to previously reported estimates using the ether plethysmographic method. The slope of pulmonary capillary blood flow (cardiac output in normal subjects) as a function of oxygen consumption during exercise in normal subjects of 0.0060 times oxygen consumption in milliliter per min was identical to published values. The rebreathing technique provides a rapid, reliable, noninvasive method for estimating pulmonary hemodynamic parameters.