Memory improvement in African Americans with amnestic mild cognitive impairment.
Memory improvement in African Americans with amnestic mild cognitive impairment.
复制标题
患有遗忘性轻度认知障碍的非裔美国人的记忆力得到改善。
DOI：
10.1002/gps.5141
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发表时间：
2019
影响因子：
4
通讯作者：
Leiby,Benjamin
中科院分区：
文献类型：
--
作者：
Rovner,BarryW;Casten,RobinJ;Leiby,Benjamin
目的遗忘型轻度认知功能障碍(amememtic轻度认知损害)的病程尚不明确。当然，评估内存变化的有效方法将最好地识别预测因素。这一问题与少数群体中的老年人尤其相关，他们可能遇到了对认知产生不利影响的生命过程因素。方法/设计生长曲线混合模型被用于确定221名患有AMCI的非裔美国人在两年内每6个月获得一次记忆测试分数的轨迹。结果参与者被分为两类，随着时间的推移，记忆分数在临床和统计学上存在显著差异。1班28例(14.7%)持续改善。2级(n=162[85.3%])得分仍然较低、波动或下降。1班的基线认知和日常生活功能较2班好。结论观察到的记忆改善率低于报道的从aMCI恢复到正常认知的比率。评估记忆测试分数的轨迹，而不是aMCI分类诊断的变化，可能取决于回忆(或不回忆)一个或两个单词，可能会产生一个更有效的认知变化指标。这些方法需要在少数群体中进一步研究。
ObjectiveAmnestic mild cognitive impairment (aMCI) has an uncertain course. Valid methods to evaluate memory change will best identify predictors of course. This issue is especially relevant to older persons in minority groups, who may have encountered life course factors that adversely affect cognition.Methods/DesignGrowth curve mixture models were used to identify trajectories of memory test scores obtained every 6 months over 2 years in 221 African Americans with aMCI.ResultsParticipants sorted into two classes, with clinically and statistically significant differences in memory scores over time. Class 1 (n = 28 [14.7%]) had sustained improved scores. Class 2 (n = 162 [85.3%]) scores remained low, fluctuated, or declined. Class 1 had better baseline cognition and daily function than class 2.ConclusionsThe observed rate of improved memory is lower than reported reversion rates from aMCI to normal cognition. Evaluating trajectories of memory test scores rather than changes in categorical diagnoses of aMCI, which may depend on recalling (or not recalling) one or two words, may yield a more valid indicator of cognitive change.These approaches require further study in minority groups.