Progenitors in motion: mechanisms of mobilization of endothelial progenitor cells
Progenitors in motion: mechanisms of mobilization of endothelial progenitor cells
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DOI：
10.1111/j.1365-2125.2009.03486.x
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发表时间：
2009-10-01
影响因子：
3.4
通讯作者：
Clapp, Brian
中科院分区：
文献类型：
--
作者：
Tilling, Lindsey;Chowienczyk, Philip;Clapp, Brian
内皮祖细胞是一群骨髓来源的单核细胞，被认为参与内皮修复，因此被认为是许多病理条件下的潜在治疗剂。它们从骨髓排出到循环和受损组织的机制（称为动员）尚未完全阐明。尽管如此，一些药理学干预已被证明会影响这些特化细胞的动员。在这里，我们回顾了目前对他们动员的理解。
Endothelial progenitor cells are a population of bone marrow-derived mononuclear cells thought to engage in endothelial repair and hence are considered potential therapeutic agents in many pathological conditions. The mechanism of their exit from the bone marrow to the circulation and damaged tissues, termed mobilization, has not been fully elucidated. Despite this, several pharmacological interventions have been shown to influence mobilization of these specialized cells. Here we review the current understanding of their mobilization.