Association of cardiorespiratory fitness on interhemispheric hippocampal and parahippocampal functional connectivity
Association of cardiorespiratory fitness on interhemispheric hippocampal and parahippocampal functional connectivity
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DOI：
10.1111/ejn.14366
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发表时间：
2019-07-01
影响因子：
3.4
通讯作者：
Loprinzi, Paul D.
中科院分区：
文献类型：
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作者：
Ikuta, Toshikazu;Loprinzi, Paul D.
大脑半球间的功能连接与认知功能有关。虽然以前的工作已经评估了认知功能的心肺健身的协会，有一个有限的调查心肺健身的记忆相关的大脑结构的功能连接的协会。因此，本研究的目的是检查心肺功能与海马旁和海马半球间功能连接之间的关联。使用Nathan Kline Institute-Rockland Sample（NKI-RS）的数据。我们的分析包括284名参与者（M年龄= 43岁; 62%女性）。使用自行车测力计协议客观地测量呼吸适应性。海马旁和海马半球间的功能连接进行了评估，从fMRI。较高的心肺适应性与海马旁区（β = 0.004; CI，0.00009至0.008，p = 0.04），但与海马（β = 0.001; CI，-0.002至0.005，p = 0.44）半球间功能连接无关。总之，增强心肺适应性可能有助于海马旁半球间的功能连接。
Interhemispheric functional connectivity is associated with cognitive functioning. Although previous work has evaluated the association of cardiorespiratory fitness on cognitive function, there has been a limited investigation of the association of cardiorespiratory fitness on the functional connectivity of memory-related brain structures. As such, the objective of this study was to examine the association between cardiorespiratory fitness and parahippocampal and hippocampal interhemispheric functional connectivity. Data from the Nathan Kline Institute-Rockland Sample (NKI-RS) were utilized. Our analysis consisted of 284 participants (M-age = 43 years; 62% female). Cardiorespiratory fitness was objectively measured using a cycle ergometer protocol. Parahippocampal and hippocampal interhemispheric functional connectivity were assessed from fMRI. Higher cardiorespiratory fitness was associated with greater parahippocampal (beta = 0.004; CI, 0.00009 to 0.008, p = 0.04), but not hippocampal (beta = 0.001; CI, -0.002 to 0.005, p = 0.44) interhemispheric functional connectivity. In conclusion, enhanced cardiorespiratory fitness may facilitate parahippocampal interhemispheric functional connectivity.