Polydrug abusers display impaired discrimination-reversal learning in a model of behavioural control
Polydrug abusers display impaired discrimination-reversal learning in a model of behavioural control
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DOI：
10.1177/0269881105057000
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发表时间：
2006-01-01
影响因子：
4.1
通讯作者：
Rush, CR
中科院分区：
文献类型：
--
作者：
Fillmore, MT;Rush, CR
长期使用可卡因和酒精与神经心理障碍有关，这涉及行为控制的抑制机制不良。本研究在一组有可卡因和重度酒精使用史的多药使用者（n = 20）和一组年龄匹配的对照组（n = 20）中测试了获得和歧视逆转学习。一个暗示去/不去任务测量受试者学习刺激反应关联的能力，包括快速激活和突然抑制反应。与对照组相比，吸毒者表现出类似的收购，但受损的歧视逆转学习的抑制和激活反应。结果表明，一些药物相关的神经心理缺陷可能反映了特定的损害能力，以抑制干扰先前的学习。这些发现有助于越来越多的证据表明，可卡因和酒精的使用可能会产生广泛的抑制性障碍，增加学习障碍和冲动控制不良的风险。
Long-term cocaine and alcohol use is associated with neuropsychological impairments that implicate poor inhibitory mechanisms of behavioural control. This study tested acquisition and discrimination-reversal learning in a group of polydrug users (n = 20) with a history of cocaine and heavy alcohol use and a group of age-matched controls (n = 20). A cued go/no-go task measured subjects' ability to learn stimulus-response associations that involved the quick activation and sudden inhibition of responses. Compared with controls, drug users displayed similar acquisition, but impaired discrimination-reversal learning of both inhibitory and activational responses. The results suggest that some drug-related neuropsychological deficits might reflect specific impairments of the ability to inhibit interference from prior learning. The findings contribute to growing evidence that suggests cocaine and alcohol use could produce broad inhibitory impairments that increase the risk for Learning deficits and poor impulse control.