Psychotic episodes during zonisamide treatment
Psychotic episodes during zonisamide treatment
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DOI：
10.1053/seiz.1999.0368
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发表时间：
2000-01-01
影响因子：
3
通讯作者：
Koyama, T
中科院分区：
文献类型：
--
作者：
Miyamoto, T;Kohsaka, M;Koyama, T
在过去的几年里，有几篇文章专门讨论了唑尼沙胺（ZNS）治疗期间的精神副作用。在这项研究中，我们对精神病发作特别感兴趣。回顾性调查了1984年3月1日至1994年6月30日期间74例有ZNS治疗史的癫痫患者。根据ZNS治疗期间精神病发作的有无分为两组。我们分析了与ZNS治疗期间精神病发作有关的各种因素。74名患者中有14人有精神病发作。我们发现，在ZNS治疗期间精神病发作的发生率比之前报道的癫痫性精神病患病率高几倍，并且在年轻患者中精神病发作的风险更高。在13例患者中，精神病发作发生在ZNS开始的几年内。在儿童中，强迫症状似乎与精神病发作有关。重要的是，如果出现精神病发作，应尽快终止ZNS，即使癫痫发作恶化，也不要重新开始。由于ZNS单一治疗期间精神副作用的信息很少，所以不能肯定地证明ZNS导致精神病发作，但在综合治疗期间，ZNS确实可能导致精神病发作。(C) 2000东亚贸易有限公司
Several articles have appeared over the last years devoted to mental side effects during zonisamide (ZNS) treatment. In this study, we were particularly interested in psychotic episodes. Seventy-four epileptic patients with a history of ZNS treatment were surveyed retrospectively over the period spanning 1 March 1984 to 30 June 1994. They were divided into two groups according to the presence or absence of psychotic episodes during ZNS treatment. We analysed various factors pertaining to psychotic episodes during ZNS treatment. Of the 74 patients 14 had psychotic episodes. We found that the incidence of psychotic episodes during ZNS treatment was several times higher than the previously reported prevalence of epileptic psychosis, and that the risk of psychotic episodes was higher in young patients. In 13 patients, psychotic episodes occurred within a few years of commencement of ZNS. In children, obsessive-compulsive symptoms appeared to be related to psychotic episodes. It is important to terminate ZNS as soon as possible if psychotic episodes develop and never restart, even if seizures become worse. It cannot definitely be proved that ZNS causes psychotic episodes, as information on mental side effects during ZNS monotherapy is scant, but it does appear likely that ZNS contributes to psychotic episodes during polytherapy. (C) 2000 BEA Trading Ltd.