The effects of diabetes on male fertility and epigenetic regulation during spermatogenesis.
The effects of diabetes on male fertility and epigenetic regulation during spermatogenesis.
复制标题
糖尿病对男性生育能力和精子发生过程中表观遗传调控的影响
DOI：
10.4103/1008-682x.150844
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发表时间：
2015-11
影响因子：
2.9
通讯作者：
Huang HF
中科院分区：
文献类型：
--
作者：
Ding GL;Liu Y;Liu ME;Pan JX;Guo MX;Sheng JZ;Huang HF
糖尿病的影响包括长期损害、功能障碍和各种器官的衰竭。糖尿病的一个重要并发症是男性生殖系统的紊乱。葡萄糖代谢是精子发生过程中的重要事件。此外，葡萄糖代谢对维持成熟精子的基本细胞活动和特定功能，如活力和受精能力也是重要的。糖尿病疾病和实验诱导的糖尿病都表明，无论是1型糖尿病还是2型糖尿病都可能对男性生育能力产生不利影响，特别是对精子质量，如精子活力、精子DNA完整性和精浆成分。表观遗传修饰在精子发生过程中是必不可少的。表观遗传调控是指染色质的修饰，包括DNA甲基化、组蛋白修饰、核小体重塑以及高阶染色质重组和非编码RNA。如果精子发生在关键发育窗口、胚胎性腺发育和生殖系分化期间受到影响，环境诱导的表观遗传修饰可能在生殖系表观基因组中成为永久性的，并通过表观遗传跨代遗传对后代产生潜在影响。糖尿病可能会影响精子发生过程中的表观遗传修饰，这些表观遗传失调可能通过男性生殖系遗传并传递给不止一代，这反过来可能会增加后代患糖尿病的风险。
The effects of diabetes mellitus include long-term damages, dysfunctions, and failures of various organs. An important complication of diabetes is the disturbance in the male reproductive system. Glucose metabolism is an important event in spermatogenesis. Moreover, glucose metabolism is also important for maintaining basic cell activity, as well as specific functions, such as motility and fertilization ability in mature sperm. Diabetic disease and experimentally induced diabetes both demonstrated that either type 1 diabetes or type 2 diabetes could have detrimental effects on male fertility, especially on sperm quality, such as sperm motility, sperm DNA integrity, and ingredients of seminal plasma. Epigenetic modifications are essential during spermatogenesis. The epigenetic regulation represents chromatin modifications including DNA methylation, histone modifications, remodeling of nucleosomes and the higher-order chromatin reorganization and noncoding RNAs. If spermatogenesis is affected during the critical developmental window, embryonic gonadal development, and germline differentiation, environmentally-induced epigenetic modifications may become permanent in the germ line epigenome and have a potential impact on subsequent generations through epigenetic transgenerational inheritance. Diabetes may influence the epigenetic modification during sperm spermatogenesis and that these epigenetic dysregulation may be inherited through the male germ line and passed onto more than one generation, which in turn may increase the risk of diabetes in offspring.