Gender difference in the association between TyG index and subclinical atherosclerosis: results from the I-Lan Longitudinal Aging Study.
Gender difference in the association between TyG index and subclinical atherosclerosis: results from the I-Lan Longitudinal Aging Study.
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DOI：
10.1186/s12933-021-01391-7
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发表时间：
2021-10-13
影响因子：
9.3
通讯作者：
Lin SJ
中科院分区：
文献类型：
--
作者：
Lu YW;Chang CC;Chou RH;Tsai YL;Liu LK;Chen LK;Huang PH;Lin SJ
胰岛素抵抗(IR)是非糖尿病患者心血管疾病(CVD)的已知危险因素，与高血糖或相关代谢因素有关。甘油三酯-血糖(TYG)指数是由血糖和胰岛素浓度定义的，作为胰岛素抵抗的替代标记物。本研究旨在探讨TYG指数与亚临床动脉粥样硬化(SA)早期阶段性别间的关系。I-Lan纵向老龄化研究(ILAS)招募了1457名年龄在50岁至80岁之间的受试者。每个受试者的人口学数据和TYG指数{ln[空腹甘油三酯(mg/dL) × 空腹血糖(mg/dL)]/2}。根据性别和TYG指数的第50个百分位数(≥ 8.55或 <； 8.55)对患者进行进一步分层。SA定义为位于整个队列第75百分位数的平均颈动脉内膜-中层厚度(CIMT)。比较两组的人口学特征和SA的存在情况。用Logistic回归分析TYG指数与SA的关系。TYG指数高(≥ 8.55)的患者有较高的体重指数、高血压和糖尿病。与甘油三酯指数较低的人( 8.55)相比，他们的血脂水平较高，包括总胆固醇(T-CHOL)和低密度脂蛋白(L DL)。在非糖尿病女性中观察到性别差异，她们在高TYG指数组中SA的患病率显著高于低TYG指数组。在多因素Logistic回归分析中，在调整了传统危险因素[调整后的优势比(OR)：1.510，95%CI 1.010-2.257，p = 0.045]后，高TYG指数在非糖尿病女性中与SA独立相关，而在非糖尿病男性中不是。TYG指数与糖尿病患者中SA的存在无关，无论性别。在非糖尿病患者中，高TYG指数与SA和性别差异显著相关。这一结果可能突出了针对性别的风险管理策略的必要性，以预防动脉粥样硬化。网上版载有补充材料，可在10.1186/s12933-021-01391-7查阅。
Insulin resistance (IR) is a known risk factor for cardiovascular disease (CVD) in non-diabetic patients through the association of hyperglycemia or associated metabolic factors. The triglyceride glucose (TyG) index, which was defined by incorporating serum glucose and insulin concentrations, was developed as a surrogate marker of insulin resistance. We aimed to investigate the association between the TyG index and the early phase of subclinical atherosclerosis (SA) between the sexes. The I-Lan Longitudinal Aging Study (ILAS) enrolled 1457 subjects aged 50–80 years. For each subject, demographic data and the TyG index {ln[fasting triglyceride (mg/dL) × fasting plasma glucose (mg/dL)]/2} were obtained. Patients were further stratified according to sex and the 50th percentile of the TyG index (≥ 8.55 or < 8.55). SA was defined as the mean carotid intima-media thickness (cIMT) at the 75th percentile of the entire cohort. Demographic characteristics and the presence of SA were compared between the groups. Logistic regression analysis was performed to assess the relationship between TyG index and SA. Patients with a higher TyG index (≥ 8.55) had a higher body mass index (BMI), hypertension (HTN) and diabetes mellitus (DM). They had higher lipid profiles, including total cholesterol (T-Chol) and low-density lipoprotein (LDL), compared to those with a lower TyG index (< 8.55). Gender disparity was observed in non-diabetic women who had a significantly higher prevalence of SA in the high TyG index group than in the low TyG index group. In multivariate logistic regression analysis, a high TyG index was independently associated with SA in non-diabetic women after adjusting for traditional risk factors [adjusted odds ratio (OR): 1.510, 95% CI 1.010–2.257, p = 0.045] but not in non-diabetic men. The TyG index was not associated with the presence of SA in diabetic patients, irrespective of sex. A high TyG index was significantly associated with SA and gender disparity in non-diabetic patients. This result may highlight the need for a sex-specific risk management strategy to prevent atherosclerosis. The online version contains supplementary material available at 10.1186/s12933-021-01391-7.
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影响因子：
5.4
作者：
Kokubo Y;Watanabe M;Higashiyama A;Nakao YM;Nakamura F;Miyamoto Y
通讯作者：
Miyamoto Y
影响因子：
7.1
作者：
KVIST, H;CHOWDHURY, B;SJOSTROM, L
通讯作者：
SJOSTROM, L
影响因子：
39.3
作者：
Dijk, Joke M.;van der Graaf, Yolanda;Algra, Ale
通讯作者：
Algra, Ale
影响因子：
2.2
作者：
Mattiasson, I;Rendell, M;Hulthén, UL
通讯作者：
Hulthén, UL
影响因子：
39.2
作者：
Hodis, HN;Mack, WJ;Azen, SP
通讯作者：
Azen, SP