State-Dependent Modification of Voltage-Gated Sodium Channels by Pyrethroids.
State-Dependent Modification of Voltage-Gated Sodium Channels by Pyrethroids.
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DOI：
10.1016/j.pestbp.2009.06.010
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发表时间：
2010-06-01
影响因子：
4.7
通讯作者：
Soderlund DM
中科院分区：
文献类型：
--
作者：
Soderlund DM
拟除虫菊酯类杀虫剂通过改变电压门控钠通道导电和不导电状态之间的快速动力学转变来破坏神经功能，这种转变是神经动作电位产生的基础。最近关于拟除虫菊酯对非洲蟾卵母细胞中表达的克隆昆虫和哺乳动物钠通道异构体作用的研究表明，在某些情况下，拟除虫菊酯的修饰要么完全依赖于通道的重复激活，要么通过通道的重复激活显着增强。这些使用依赖性效应被解释为至少一些拟除虫菊酯优先结合到钠通道的开放状态，而不是静止状态的证据。本文综述了拟除虫菊酯对昆虫和哺乳动物卵母细胞中表达的钠通道的状态依赖性修饰的证据，并考虑了状态依赖性效应对理解拟除虫菊酯作用的分子机制以及拟除虫菊酯受体模型的开发和测试的意义。
Pyrethroids disrupt nerve function by altering the rapid kinetic transitions between conducting and nonconducting states of voltage-gated sodium channels that underlie the generation of nerve action potentials. Recent studies of pyrethroid action on cloned insect and mammalian sodium channel isoforms expressed in Xenopus laevis oocytes show that in some cases pyrethroid modification is either absolutely dependent on or significantly enhanced by repeated channel activation. These use-dependent effects have been interpreted as evidence of preferential binding of at least some pyrethroids to the open, rather than resting, state of the sodium channel. This paper reviews the evidence for state-dependent modification of insect and mammalian sodium channels expressed in oocytes by pyrethroids and considers the implications of state-dependent effects for understanding the molecular mechanism of pyrethroid action and the development and testing of models of the pyrethroid receptor.
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影响因子：
4.1
作者：
O'Reilly, Andrias O.;Khambay, Bhupinder P. S.;Davies, T. G. Emyr
通讯作者：
Davies, T. G. Emyr
影响因子：
2.9
作者：
LOMBET, A;MOURRE, C;LAZDUNSKI, M
通讯作者：
LAZDUNSKI, M
DOI：
10.1016/s0169-328x(96)00241-0
发表时间：
1997-04-01
期刊：
MOLECULAR BRAIN RESEARCH
影响因子：
--
作者：
Felts, PA;Yokoyama, S;Waxman, SG
通讯作者：
Waxman, SG
影响因子：
2.5
作者：
Choi, JS;Soderlund, DM
通讯作者：
Soderlund, DM
影响因子：
3.8
作者：
Meacham, Connie A.;Brodfuehrer, Peter D.;Shafer, Timothy J.
通讯作者：
Shafer, Timothy J.