RADIATION-INDUCED MUTATION RATES IN FEMALE MICE.
RADIATION-INDUCED MUTATION RATES IN FEMALE MICE.
复制标题
雌性小鼠中辐射诱发的突变率。
DOI：
10.1073/pnas.44.9.901
复制
发表时间：
1958
影响因子：
11.1
通讯作者：
S. Maddux
中科院分区：
文献类型：
--
作者：
W. Russell;L. B. Russell;J. Gower;S. Maddux
在两个实验中，用特异位点法测定了女性的突变率。一项相对较小的急性x射线实验，其剂量使女性迅速绝育，但足以表明，如果两性平等暴露于急性x射线的平均风险是根据在男性中确定的更可靠的比率来计算的，那么几乎可以肯定，这种危害的低估程度不会超过2倍。一项用慢性伽玛射线进行的实验，使雌性几乎可以正常生育，迄今为止，给大鼠5 × 10/sup -8/r/位点，95%的置信区间为0.8到18 × 10/sup -8/。该大鼠明显低于相同剂量急性x射线照射下雄性大鼠的28 × 10/sup -8/r/位点。讨论了较低比率的可能原因。无论解释是什么，结果表明，暴露于慢性伽马辐射的女性中的突变大鼠可能低于我们先前的标准所估计的，即从雄性小鼠的急性x射线照射中获得的突变率。(认证)
Mutation rates in females have been measured by the specific locus method in two experiments. A relatively small experiment with acute x rays, at a dose which rapidly sterilizes females, was nevertheless sufficient to show that if the average risk of equal exposure of both sexes to acute x rays is calculated on the basis of the far more reliable rate determined in males, the hazard will almost certainly not be underestimated by more than a factor of 2. An experiment with chronic gamma rays, which allowed almost normal fertility of the females, has, to date, given a rats of 5 x 10/sup -8/r/ locus with a 95 per cent confidence interval of 0.8 to 18 x 10/sup -8/. This rats is significantly below that of 28 x 10/sup -8/r/locus found in males irradiated with a similar dose of acute x irradiation. Possible reasons for the lower rate are discussed. Whatever the explanation turns out to be, the results indicate that the mutation rats in women exposed to chronic gamma radiation may be less than that estimated from our earlier yardstick, namely, the mutation rate obtained from acute x irradiation of male mice. (auth)