Comparison of glyburide and insulin for the management of gestational diabetes in a large managed care organization
Comparison of glyburide and insulin for the management of gestational diabetes in a large managed care organization
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DOI：
10.1016/j.ajog.2005.03.018
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发表时间：
2005-07-01
影响因子：
9.8
通讯作者：
Field, DR
中科院分区：
文献类型：
--
作者：
Jacobson, GF;Ramos, GA;Field, DR
目的：本研究进行了比较使用格列本脲与胰岛素的治疗妊娠期糖尿病（GDM）无反应的饮食therapy.Study设计：一项回顾性研究中进行单胎妊娠的妇女谁有GDM诊断，空腹血糖140毫克/分升或更低的葡萄糖耐量试验，12至34周之间的饮食治疗失败，从1999年至2002年。我们确定了584名妇女，并将1999年至2000年期间接受胰岛素治疗的妇女与2001年至2002年期间接受格列本脲治疗的妇女进行了比较。评估产妇和新生儿结局和并发症。统计方法包括单变量分析和多变量logistic regression.Results：在1999年至2000年，268名妇女有GDM诊断和胰岛素治疗，在2001年至2002年，316名妇女有GDM诊断，其中236（75%）收到格列本脲。两组在年龄、未经产和GDM病史危险因素方面相似;然而，胰岛素组妇女的平均体重指数较高（31.9 vs 30.6 kg/m2，p = 0.04），更大比例的妇女认为自己是白色（43%，28%，P
Objective: This study was undertaken to compare the use of glyburide with insulin for the treatment of gestational diabetes mellitus (GDM) unresponsive to diet therapy.Study design: A retrospective study was performed among women with singleton pregnancies who had GDM diagnosed, with fasting plasma glucose 140 mg/dL or less on glucose tolerance testing, between 12 and 34 weeks who failed diet therapy from 1999 to 2002. We identified 584 women and compared those treated with insulin between 1999 and 2000 with women treated with glyburide between 2001 and 2002. Maternal and neonatal outcomes and complications were assessed. Statistical methods included univariate analyses and multivariable logistic regression.Results: In 1999 through 2000, 268 women had GDM diagnosed and were treated with insulin; in 2001 through 2002, 316 women had GDM diagnosed of which 236 (75%) received glyburide. The 2 groups were similar with regard to age, nulliparity, and historical GDM risk factors; however, women in the insulin group had a higher mean body mass index (31.9 vs 30.6 kg/m(2), p =.04), a greater proportion identified themselves as white (43%, 28%, P