Changes in ornithine decarboxylase activity during matrix-induced cartilage, bone and bone marrow differentiation.
Changes in ornithine decarboxylase activity during matrix-induced cartilage, bone and bone marrow differentiation.
复制标题
基质诱导的软骨、骨和骨髓分化过程中鸟氨酸脱羧酶活性的变化。
DOI：
10.1016/0006-291x(78)91636-4
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发表时间：
1978
影响因子：
3.1
通讯作者：
A. Reddi
中科院分区：
文献类型：
--
作者：
N. Rath;A. Reddi
将脱矿大鼠骨干骨基质粗粉皮下移植到异体受体中可形成新骨。研究了骨基质诱导的软骨、骨和骨髓序贯分化过程中鸟氨酸脱羧酶活性的变化。鸟氨酸脱羧酶活性在第3天达到峰值，与成纤维细胞靠近骨基质的出现相对应。在第8天，酶活性又达到了一个高峰，这与假定的成骨细胞和血管内皮细胞的增殖有关。鸟氨酸脱羧酶活性在第3天达到峰值，似乎是骨基质脱矿特异性事件。鸟氨酸脱羧酶活性的诱导是对植入骨基质的早期反应之一。
Subcutaneous transplantation of coarse powders of demineralized rat diaphyseal bone matrix into allogeneic recipients results in new bone formation. The changes in ornithine decarboxylase activity during such bone matrix-induced sequential differentiation of cartilage, bone and bone marrow were investigated. There was a peak in ornithine decarboxylase activity on day 3 corresponding to the appearance of fibroblasts in close contiguity to the bone matrix. This was followed by another peak of enzyme activity on day 8 which was correlated with the onset of proliferation of presumptive osteoblasts and vascular endothelial cells. The peak of ornithine decarboxylase activity on day 3 appears to be a demineralized bone matrix-specific event. Induction of ornithine decarboxylase activity represents one of the early responses to implanted bone matrix.