Dynamic Corticospinal White Matter Connectivity Changes During Stroke Recovery: A Diffusion Tensor Probabilistic Tractography Study
Dynamic Corticospinal White Matter Connectivity Changes During Stroke Recovery: A Diffusion Tensor Probabilistic Tractography Study
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DOI：
10.1002/jmri.21627
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发表时间：
2009-03-01
影响因子：
4.4
通讯作者：
Rose, Stephen E.
中科院分区：
文献类型：
--
作者：
Pannek, Kerstin;Chalk, Jonathan B.;Rose, Stephen E.
目的：研究脑卒中恢复期皮质表面皮质脊髓束的弥散张量成像（DTI）纤维束成像改变。材料与方法：使用10名中风患者的数据（4个皮层下）和6个老年对照组，我们开发了一种自动化的方法来量化改变的运动连接，该方法涉及使用简化的皮质表面模型作为种子掩模，在皮质脊髓内定义目标区域。tracts启动一个概率tractography algorithm.Results：我们发现没有变化的体积重叠的脑卒中患者中生成的皮质脊髓束相比，控制，但显着的连接变化的边界简化的皮质表面掩模，特别是在同病灶半球的脑卒中患者随着时间的推移。使用具有显著增强的连通性的皮层区域作为患者数据上的种子掩模，可以描绘与中风恢复直接相关的神经束。这些纤维束内的纤维方向的不确定性的措施显着conelated与功能outcome.Conclusion：从这项研究的新发现突出了这种方法的有用性研究白色物质修复/重组中风恢复。
Purpose: To investigate corticospinal tract connectivity changes at the cortical surface using diffusion tensor imaging (DTI) tractography during recovery from stroke.Materials and Methods: Using data from 10 stroke patients (four subcortical) and six elderly controls, we developed an automated method to quantify altered motor connectivity that involves the use of a simplified cortical surface model as a seed mask with target regions defined within the corticospinal tracts to initiate a probabilistic tractography algorithm.Results: We found no change in volume overlap of the generated corticospinal tracts in the stroke patients compared to controls, but significant connectivity changes at the boundary of the simplified cortical surface mask, especially within the ipsilesional hemisphere of stroke patients over time. Using the cortical regions with significantly enhanced connectivity as a seed mask on the patient data, tracts that are directly associated with stroke recovery can be delineated. Measures of uncertainty in fiber orientation within these fiber tracts significantly con-elated With functional outcome.Conclusion: The novel findings from this study highlight the usefulness of this methodology to study white matter repair/reorganization during stroke recovery.