Thalamic lesion and epilepsy with generalized seizures, ESES and spike-wave paroxysms -: Report of three cases
Thalamic lesion and epilepsy with generalized seizures, ESES and spike-wave paroxysms -: Report of three cases
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DOI：
10.1016/j.seizure.2006.05.006
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发表时间：
2006-09-01
影响因子：
3
通讯作者：
Halasz, Peter
中科院分区：
文献类型：
--
作者：
Kelemen, Anna;Barsi, Peter;Halasz, Peter
本文报告三位丘脑病变合并全身性癫痫的病人，其癫痫表现为全身性棘波。前2例均为单侧围产期损害，1例为觉醒时全身强直阵挛性发作，另1例为朗道-克-雷氏综合征。在疾病的过程中，这两个孩子都发展成stow波陡峭的癫痫性电持续状态（ESES）。第三个病人有一个占主导地位的单侧丘脑肿瘤和癫痫，模仿青少年肌阵挛性癫痫。本文讨论了丘脑和丘脑底核团在广义棘波电图中的作用，着重讨论了齿状回抑制系统的可能机制。(C)2006年英国癫痫协会。由爱思唯尔有限公司出版。保留所有权利。
We report three patients, who have thalamic lesion and secondary generalized epilepsy with generalized spike wave pattern. The first two patients have unilateral perinatal lesion, one with generalized tonic-clonic seizures on awakening the other with Landau- Kleffner-like syndrome. During the course of the disease both children developed electrical status epilepticus in stow wave steep (ESES). The third patient has a dominantly unilateral thalamic tumor and epilepsy that mimics juvenile myoclonic epilepsy. All the patients have a lesion located in the inferior- medial- posterior part of the thalamus.The role of some thalamic and subthalamic nuclei in the generalized spike-wave electrical pattern patophysiology is discussed, with emphasis on the possible rote of the inhibitory system from the zona incerta. (C) 2006 British Epilepsy Association. Published by Elsevier Ltd. All rights reserved.