A HYDROPHILIC TETRAHYDRO-BETA-CARBOLINE IN HUMAN URINE
A HYDROPHILIC TETRAHYDRO-BETA-CARBOLINE IN HUMAN URINE
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DOI：
10.1093/oxfordjournals.jbchem.a124343
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发表时间：
1994-02-01
影响因子：
2.7
通讯作者：
FUJISE, Y
中科院分区：
文献类型：
--
作者：
HORIUCHI, K;YONEKAWA, O;FUJISE, Y
从人尿中分离出一种在中性pH下295 nm处激发时在354nm处出现色氨酸样荧光峰的物质。通过可见光吸收光谱、荧光光谱、H-1和C-13核磁共振光谱以及FAB-MS测定该化合物为1-（1′，2′，3′，4′，5′-五羟基戊基）-1,2,3,4-四氢-2-羰基-3-羧酸。该化合物命名为tetrahydropentoxyline，是一种新型亲水性四氢- β -羰基胺，在C-18反相高效液相色谱上，其洗脱位置介于4-吡啶酸和犬尿酸之间。正常人尿中四氢己碱排泄量[n=21；年龄，45 （SD 20）岁)约为每天5.2 (SD 1.0) mg。
A substance that exhibited a tryptophan-like fluorescence peak at 354 nm on excitation at 295 nm at neutral pH was isolated from human urine. This compound was determined by visible-light absorption spectroscopy, fluorescence spectroscopy, H-1 and C-13 NMR spectroscopies, and FAB-MS to be 1-(1',2',3',4',5' -pentahydroxypentyl)-1,2,3,4-tetrahydro-2-carboline-3-carboxylic acid. This compound, named tetrahydropentoxyline, is a new type of hydrophilic tetrahydro-beta-carboline, and its elution position was between those of 4-pyridoxic acid and kynurenic acid on C-18 reversed-phase HPLC. The amount of tetrahydropentoxyline excreted in the urine of normal subjects [n=21; age, 45 (SD 20) years] was about 5.2 (SD 1.0) mg per day.