A Search for Parent-of-Origin Effects on Honey Bee Gene Expression.
A Search for Parent-of-Origin Effects on Honey Bee Gene Expression.
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DOI：
10.1534/g3.115.017814
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发表时间：
2015-06-05
期刊：
影响因子：
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通讯作者：
Hunt GJ
中科院分区：
文献类型：
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作者：
Kocher SD;Tsuruda JM;Gibson JD;Emore CM;Arechavaleta-Velasco ME;Queller DC;Strassmann JE;Grozinger CM;Gribskov MR;San Miguel P;Westerman R;Hunt GJ
亲本特异性基因表达（PSGE）在哺乳动物和植物之外知之甚少。当基因的表达水平取决于等位基因是从母亲还是父亲遗传时，PSGE就会发生。亲属选择理论预测，社会性昆虫中应该存在广泛的PSGE，因为社会性昆虫亲本可以通过沉默雌性后代中的亲本等位基因来获得包容性适合度益处。我们使用欧洲和非洲化菌株之间的相互杂交的转录组在蜜蜂中寻找PSGE的证据。我们发现46个转录本对基因表达具有显着的亲本效应，其中许多转录本过度表达了母系等位基因。有趣的是，我们还发现了一个很大比例的基因显示出偏向母系等位基因，只有一个正反交。这些结果表明，PSGE可能发生在社会昆虫。这些菌株之间的杂交不亲和性可能在很大程度上驱动的非互惠效应。未来的工作将有助于确定这些是否确实是父母的原产地的影响，可以调节包容性健身的好处。
Parent-specific gene expression (PSGE) is little known outside of mammals and plants. PSGE occurs when the expression level of a gene depends on whether an allele was inherited from the mother or the father. Kin selection theory predicts that there should be extensive PSGE in social insects because social insect parents can gain inclusive fitness benefits by silencing parental alleles in female offspring. We searched for evidence of PSGE in honey bees using transcriptomes from reciprocal crosses between European and Africanized strains. We found 46 transcripts with significant parent-of-origin effects on gene expression, many of which overexpressed the maternal allele. Interestingly, we also found a large proportion of genes showing a bias toward maternal alleles in only one of the reciprocal crosses. These results indicate that PSGE may occur in social insects. The nonreciprocal effects could be largely driven by hybrid incompatibility between these strains. Future work will help to determine if these are indeed parent-of-origin effects that can modulate inclusive fitness benefits.