A General Strategy To Construct Fluorogenic Probes from Charge-Generation Polymers (CGPs) and AIE-Active Fluorogens through Triggered Complexation
A General Strategy To Construct Fluorogenic Probes from Charge-Generation Polymers (CGPs) and AIE-Active Fluorogens through Triggered Complexation
复制标题
通过触发络合从电荷产生聚合物 (CGP) 和 AIE 活性荧光剂构建荧光探针的通用策略
DOI：
10.1002/anie.201105735
复制
发表时间：
2012-01-01
影响因子：
16.6
通讯作者：
Liu, Shiyong
中科院分区：
文献类型：
--
作者：
Li, Changhua;Wu, Tao;Liu, Shiyong
Fluorescent probes have been extensively used in chemical biology, clinical diagnosis, and biosensing because of their high sensitivity, fast response, and excellent spatial and temporal resolution.[1] On the basis of photo-induced electron transfer (PET), internal charge transfer (ICT), fluorescence resonance energy transfer (FRET), and excited-state intramolecular proton transfer (ESIPT) mechanisms, various fluorometric probes based on small molecule fluorophores, quantum dots, and conjugated polymers have been developed.[2] The concept of aggregation-induced emission (AIE)[3] or aggregation-induced enhanced emission (AIEE)[4] has emerged to be a powerful and versatile strategy for the design of novel types of fluorescent probes.[5] Typical AIE-active molecules, such as tetraphenylethene (TPE), are non-emissive in the molecularly dissolved state, whereas enhanced fluorescence emission was achieved when they are in the aggregated state.[6] In recent years, a great variety of AIE-based small-molecule chemosensors and biosensors for analytes ranging from heavy-metal ions, thiols, explosives, gas, carbohydrates, and DNA, to proteins and enzymes have been fabricated.[5–7] Current research trends in this field involve the development of general strategies towards water-soluble fluorogenic probes selective and sensitive for variable analytes.Polyelectrolytes undergo aggregation and assembly in the presence of oppositely charged polyelectrolytes, multivalent small organic molecules, and inorganic nanoparticles owing to electrostatic interactions.[8] However, to the best of our knowledge, polyelectrolyte-induced aggregation of AIE-active charged fluorogens has not been utilized in sensing and detection systems, mainly because of the lack of suitable smart polyelectrolytes exhibiting specific analyte-triggerable charge generation or conversion characteristics. It can be
