Patient Selection for Clinical Trials Using Temporalized Ontology-Mediated Query Answering
Patient Selection for Clinical Trials Using Temporalized Ontology-Mediated Query Answering
复制标题
DOI：
10.1145/3184558.3191538
复制
发表时间：
2018-04
期刊：
影响因子：
--
通讯作者：
F. Baader;Stefan Borgwardt;Walter Forkel
中科院分区：
文献类型：
--
作者：
F. Baader;Stefan Borgwardt;Walter Forkel
为临床试验寻找合适的候选人是一项劳动密集型任务，需要专业的医学知识。我们的目标是设计（半）自动化技术，可以支持临床研究人员在这项任务。我们调查的问题，在设计正式的查询语言，选择患者有资格参加一个给定的临床试验，利用现有的基于本体的查询回答技术。特别是，我们建议使用现有的方法，通过描述逻辑编写的本体访问数据的时间扩展。我们勾勒出这样一个查询应答系统可以工作，并表明，资格标准和患者数据可以充分模拟在我们的形式主义。
Finding suitable candidates for clinical trials is a labor-intensive task that requires expert medical knowledge. Our goal is to design (semi-)automated techniques that can support clinical researchers in this task. We investigate the issues involved in designing formal query languages for selecting patients that are eligible for a given clinical trial, leveraging existing ontology-based query answering techniques. In particular, we propose to use a temporal extension of existing approaches for accessing data through ontologies written in Description Logics. We sketch how such a query answering system could work and show that eligibility criteria and patient data can be adequately modeled in our formalism.