Food iron absorption in man. Applications of the two-pool extrinsic tag method to measure heme and nonheme iron absorption from the whole diet.
Food iron absorption in man. Applications of the two-pool extrinsic tag method to measure heme and nonheme iron absorption from the whole diet.
复制标题
人体对食物铁的吸收。
DOI：
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发表时间：
1974
影响因子：
15.9
通讯作者：
B. Arvidsson
中科院分区：
文献类型：
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作者：
E. Björn;L. Hallberg;B. Isaksson;B. Arvidsson
本研究采用了一种新的放射性同位素方法来测量整个饮食中的铁吸收量。该方法基于食物铁从血红素铁池和非血红素铁池两种池中吸收的概念，特别是可以用血红素和铁盐两种放射性铁同位素进行标记。本研究的目的是检验这种双池外部标签方法的准确性。所提供的膳食由32名年轻士兵的平均6周消耗量组成。32名青年男性血红素铁和非血红素铁的平均和总吸收率为1.01+/-0.11。这个数字与这组受试者预期的平均每日损失（1.0毫克）非常吻合。因此，可以得出结论，本方法测量混合饮食中铁的总吸收量没有重大的系统误差。在一个系列中，比较了从膳食中吸收血红素和非血红素铁。发现两种铁的吸收率之间有显著的相关性。然而，血红素铁被吸收的比例（37%）比非血红素铁（5%）要高得多。早餐和午餐的吸收分为两个系列，可以很好地预测每日非血红素铁的总吸收。其中一个系列是用来比较两种铁强化水平的效果。当膳食中铁强化水平增加时，铁的吸收量显著增加。
A new radioisotope method to measure iron absorption from the whole diet was used in this study. The method is based on the concept that food iron is absorbed from two pools, the heme iron pool and the nonheme iron pool, which can be especially labeled with two radioiron isotopes given as hemoglobin and as an iron salt. The purpose of this study was to test the accuracy of this two-pool extrinsic tag method. The meals served were composed as an average of 6 wk consumption in the present material of 32 young enlisted men. The mean and total heme and nonheme iron absorption in all the 32 young men was 1.01+/-0.11. This figure agrees well with the mean daily losses expected for this group of subjects (1.0 mg). The conclusion can therefore be made that there are no major systematic errors of the present method to measure the total iron absorption from a mixed diet. In one series a comparison was made of the absorption of heme and nonheme iron from the meals. A significant correlation between the absorption of the two kinds of iron was found. However, a much greater fraction of the heme iron was absorbed (37%) than of the nonheme iron (5%). The absorption both from breakfast and lunch was in two series found to give a good prediction of the total daily nonheme iron absorption. One series was designed to compare the effect of two levels of iron fortification. There was a significant increase in iron absorption when the level of iron fortification of the meals was increased.