Brain activity underlying encoding and retrieval of source memory
Brain activity underlying encoding and retrieval of source memory
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DOI：
10.1093/cercor/12.10.1048
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发表时间：
2002-10-01
期刊：
影响因子：
3.7
通讯作者：
Rugg, MD
中科院分区：
文献类型：
--
作者：
Cansino, S;Maquet, P;Rugg, MD
通过事件相关功能磁共振成像（efMRI）研究了源信息编码和检索过程中引发的神经活动。在编码过程中，17 名受试者对随机呈现在显示器四个象限之一的常见物体的图片进行自然/人工判断。在检索时，旧图片与新图片混合在一起，受试者判断每张图片是新的还是旧的，如果是旧的，则指出它在编码时出现在哪个象限中。在编码过程中，后来被识别并分配了正确源判断的研究项目比在多个区域（包括右侧枕叶和左前额叶皮层）给出错误判断的已识别项目引发了更大的活动。在检索时，相对于错误的源判断，对已识别项目表现出更大活动的区域包括右侧海马结构和左侧前额叶皮层。这些发现表明这些区域在情景信息的编码和检索中的作用超出了简单项目识别所需的范围。
Neural activity elicited during the encoding and retrieval of source information was investigated with event-related functional magnetic resonance imaging (efMRI). During encoding, 17 subjects performed a natural/artificial judgement on pictures of common objects which were presented randomly in one of the four quadrants of the display. At retrieval, old pictures were mixed with new ones and subjects judged whether each picture was new or old and, if old, indicated in which quadrant it was presented at encoding. During encoding, study items that were later recognized and assigned a correct source judgement elicited greater activity than recognized items given incorrect judgements in a variety of regions, including right lateral occipital and left prefrontal cortex. At retrieval, regions showing greater activity for recognized items given correct versus incorrect source judgements included the right hippocampal formation and the left prefrontal cortex. These findings indicate a role for these regions in the encoding and retrieval of episodic information beyond that required for simple item recognition.