Immunologic relatedness of papillomaviruses from different species.
Immunologic relatedness of papillomaviruses from different species.
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不同物种的乳头瘤病毒的免疫学相关性。
DOI：
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发表时间：
1980
期刊：
影响因子：
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通讯作者：
K. Shah
中科院分区：
文献类型：
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作者：
A. B. Jenson;J. Rosenthal;C. Olson;F. Pass;W. Lancaster;K. Shah
免疫兔与十二烷基硫酸钠破坏的病毒粒子从一个池的足底疣制备的抗血清与病毒阳性的乳头状瘤的其他动物物种的疣组织的冷冻切片和过氧化物酶-抗过氧化物酶试验的切片福尔马林固定的组织的间接免疫荧光试验交叉反应。抗血清染色的足底疣，疣和疣状表皮发育不良的皮肤病变，所有来自人类;牛纤维乳头状瘤，实验产生的牛1型和2型;和传染性犬口腔乳头状瘤。染色定位于上皮细胞上颗粒层的细胞核，并且在分布上与针对该乳头瘤病毒特异性制备的抗血清产生的图案相似。抗血清不染色病毒阴性疣，或感染simlan病毒40，人多瘤病毒BK，和鼠多瘤病毒的细胞。这些数据表明，乳头瘤病毒共享一个共同的内部抗原，与先前描述的多瘤病毒（包括猿猴病毒40和多瘤病毒亚组）的类似抗原无关。
An antiserum prepared by immunization of a rabbit with sodium dodecyl sulfate-disrupted virions from a pool of plantar warts was cross-reactive with virus-positive papillomas of other animal species by both indirect immunofluorescence tests on frozen sections of wart tissues and peroxidase-antiperoxidase tests of sections of Formalin-fixed tissues. The antiserum stained plantar warts, common warts, and skin lesions of epidermodysplasia verruciformis, all from humans; bovine fibropapilloma, experimentally produced with bovine types 1 and 2; and transmissible canine oral papillomas. The staining was localized to nuclei of the upper granular layers of the peithelium and was similar in distribution to the pattern produced by antiserum specifically prepared against that papillomavirus. The antiserum did not stain virus-negative warts, or cells infected with simlan virus 40, human polyomavirus BK, and murine polyomavirus. These data suggested that papillomaviruses share a common internal antigen unrelated to a similar antigen described previously for the polyomaviruses (which include simian virus 40 and polyomavirus subgroups).