Peroxisome proliferator-activated receptor (PPAR) gamma: adipose-predominant expression and induction early in adipocyte differentiation.
Peroxisome proliferator-activated receptor (PPAR) gamma: adipose-predominant expression and induction early in adipocyte differentiation.
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DOI：
10.1210/endo.135.2.8033830
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发表时间：
1994-08
期刊：
影响因子：
4.8
通讯作者：
A. Chawla;E. Schwarz;D. Dimaculangan;M. Lazar
中科院分区：
文献类型：
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作者：
A. Chawla;E. Schwarz;D. Dimaculangan;M. Lazar
过氧化物酶体增殖物激活受体（peroxisomeproliferatoractivatedreceptor，PPAR）激活剂可调节脂肪酸代谢并诱导脂肪细胞分化。我们在这里表明，γ亚型的过氧化物酶体增殖物激活受体在脂肪组织中表达水平高，而在其他各种组织中，很少有基因表达。此外，3 T3-L1前脂肪细胞中存在低水平的PPAR γ，并且在使用正常分化条件（胎牛血清、地塞米松、异丁基-甲基黄嘌呤和胰岛素）或PPAR激活剂WY-14，643的脂肪细胞转化过程中显著诱导。因此，过氧化物酶体增殖物激活受体γ可能是重要的脂肪细胞的发育和功能。
Activators of peroxisome proliferator activated receptor (PPAR) regulate fatty acid metabolism and can induce adipocyte differentiation. We show here that the gamma subtype of PPAR is expressed at high levels in adipose tissue in contrast to a variety of other tissues, where little gene expression was noted. In addition, PPAR gamma is present at low levels in 3T3-L1 preadipocytes and is induced dramatically during adipocyte conversion using either normal differentiating conditions (fetal calf serum, dexamethasone, isobutyl-methylxanthine, and insulin) or the PPAR activator, WY-14,643. Thus PPAR gamma may be important for adipose cell development and function.