BORNA DISEASE VIRUS, A NEGATIVE-STRAND RNA VIRUS, TRANSCRIBES IN THE NUCLEUS OF INFECTED-CELLS
BORNA DISEASE VIRUS, A NEGATIVE-STRAND RNA VIRUS, TRANSCRIBES IN THE NUCLEUS OF INFECTED-CELLS
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DOI：
10.1073/pnas.89.23.11486
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发表时间：
1992-12-01
影响因子：
11.1
通讯作者：
LIPKIN, WI
中科院分区：
文献类型：
--
作者：
BRIESE, T;DELATORRE, JC;LIPKIN, WI
博尔纳病病毒（Borna disease virus，Borna）是一种未分类的病原体，可引起多种动物免疫介导的神经系统疾病，并可能参与人类神经精神疾病的发病。我们在这里描述了一种分离病毒颗粒的方法，该方法允许明确鉴定基因组中含有负极性RNA。此外，我们表明，病毒的mRNA在细胞核中转录。
Borna disease virus, an unclassified infectious agent, causes immune-mediated neurologic disease in a wide variety of animal hosts and may be involved in pathogenesis of selected neuropsychiatric diseases in man. Initial reports suggested that Borna disease virus is a single-stranded RNA virus. We describe here a method for isolation of viral particles that has allowed definitive identification of the genome as containing a negative-polarity RNA. Further, we show that the viral mRNAs are transcribed in the nucleus.