Activity patterns of serotonin neurons underlying cognitive flexibility
Activity patterns of serotonin neurons underlying cognitive flexibility
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DOI：
10.7554/elife.20552
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发表时间：
2017-03-21
期刊：
影响因子：
7.7
通讯作者：
Mainen, Zachary F.
中科院分区：
文献类型：
--
作者：
Matias, Sara;Lottem, Eran;Mainen, Zachary F.
血清素与情绪和情感障碍有关。然而，越来越多的证据表明，一个核心的内源性作用是通过行为抑制和增强可塑性，促进灵活适应环境因果结构的变化。我们使用小鼠的长期光度记录来研究中缝背核5-羟色胺神经元的群体，我们可以使用药物遗传学将其活动与正常的逆转学习联系起来。我们发现，这些神经元被积极和消极的预测错误激活，因此报告的信号类似于在不确定条件下促进学习的信号。此外，通过比较5-羟色胺和多巴胺神经元的提示反应，我们发现学习率的差异可以解释5-羟色胺在抑制持续反应中的重要性。我们的研究结果显示了5-羟色胺神经元的活动模式如何支持认知灵活性的作用，并提出了一个具有潜在临床意义的多巴胺-5-羟色胺毒性的修正模型。
Serotonin is implicated in mood and affective disorders. However, growing evidence suggests that a core endogenous role is to promote flexible adaptation to changes in the causal structure of the environment, through behavioral inhibition and enhanced plasticity. We used long-term photometric recordings in mice to study a population of dorsal raphe serotonin neurons, whose activity we could link to normal reversal learning using pharmacogenetics. We found that these neurons are activated by both positive and negative prediction errors, and thus report signals similar to those proposed to promote learning in conditions of uncertainty. Furthermore, by comparing the cue responses of serotonin and dopamine neurons, we found differences in learning rates that could explain the importance of serotonin in inhibiting perseverative responding. Our findings show how the activity patterns of serotonin neurons support a role in cognitive flexibility, and suggest a revised model of dopamine-serotonin opponency with potential clinical implications.