Glucocorticoids reverse leptin effects on food intake and body fat in mice without increasing NPY mRNA.
Glucocorticoids reverse leptin effects on food intake and body fat in mice without increasing NPY mRNA.
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糖皮质激素逆转瘦素对小鼠食物摄入和体脂的影响，而不增加 NPY mRNA。
DOI：
10.1152/ajpendo.1999.277.4.e708
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发表时间：
1999
期刊：
影响因子：
--
通讯作者：
Jacobson,L
中科院分区：
文献类型：
--
作者：
Solano,JM;Jacobson,L
Glucocorticoid stimulation of appetite and leptin expression conflicts with leptin inhibition of food intake and suggests that glucocorticoids reduce sensitivity to leptin. To determine if glucocorticoids impair feeding and metabolic responses to leptin, we measured leptin-induced changes in food intake, body weight, hormones, carcass fat, and hypothalamic neuropeptide Y (NPY) mRNA in adrenalectomized mice with and without corticosterone replacement. Leptin infusion (0.5 μg/h) significantly decreased food intake and body weight in adrenalectomized mice. Corticosterone replacement approximating normal 24-h mean levels restored food intake but did not permit weight gain equivalent to PBS-infused controls. Corticosterone levels comparable to stress-induced production completely reversed leptin-induced reductions in weight gain and body fat, despite significant attenuation by leptin of corticosterone-induced increases in plasma insulin levels. Glucocorticoid replacement increased food intake without reversing leptin inhibition of hypothalamic NPY mRNA levels. We conclude that glucocorticoid levels within the physiological range can interfere with leptin action and that glucocorticoid effects are at least partly independent of NPY.
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DOI：
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