Evolution, biochemistry and genetics of protein kinase C in fungi
Evolution, biochemistry and genetics of protein kinase C in fungi
复制标题
真菌中蛋白激酶C的进化、生物化学和遗传学
作者:
H. Schmitz;J. Heinisch
Abstract. From yeast to humans, protein kinase C is an enzyme of central importance in signal transduction processes. In baker's yeast, Saccharomyces cerevisiae, a single gene encoding Pkc1p has been identified. Mutant analyses revealed that Pkc1p function is essential to ensure cellular integrity through regulation of a specific MAP kinase cascade. Due to the involvement of different defective mammalian isozymes in various diseases and the model character of simple eukaryotes, increasing attention has been paid to the structure and regulation of the enzymes of fungal origin. This review summarizes the knowledge gathered so far.
登录
查看更多内容
影响因子:
4.3
作者:
Park,H;Lennarz,WJ
通讯作者:
Lennarz,WJ
影响因子:
4
作者:
P. D. Andrews;M. Stark
通讯作者:
P. D. Andrews;M. Stark
DOI:
--
发表时间:
1994
期刊:
Cellular & molecular biology research
影响因子:
--
作者:
D. E. Levin;B. Bowers;C. Y. Chen;Y. Kamada;M. Watanabe
通讯作者:
D. E. Levin;B. Bowers;C. Y. Chen;Y. Kamada;M. Watanabe
DOI:
--
发表时间:
1994-06
期刊:
The Journal of biological chemistry
影响因子:
--
作者:
M. Watanabe;Cheau-Yun Chen;D. E. Levin
通讯作者:
M. Watanabe;Cheau-Yun Chen;D. E. Levin