The Molecular Basis of Predicting Atherosclerotic Cardiovascular Disease Risk.
The Molecular Basis of Predicting Atherosclerotic Cardiovascular Disease Risk.
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DOI：
10.1161/circresaha.120.315890
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发表时间：
2021-01-22
影响因子：
20.1
通讯作者：
Vasan RS
中科院分区：
文献类型：
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作者：
Nayor M;Brown KJ;Vasan RS
动脉粥样硬化性心血管疾病 (ASCVD) 会经历一系列阶段：起始、进展（或消退）和并发症。通过将有关每个阶段分子特征的已知生物学与高维分子数据采集平台（用于分析基因组、表观基因组、转录组、蛋白质组、代谢组和肠道微生物组）的最新进展相结合，可以捕获 ASCVD 发展每个阶段的“快照”。在这篇综述中，我们将总结使用外周血分子特征和分子成像方法评估人类 ASCVD 疾病风险的新兴方法。然后，我们将讨论将这些快照集成到个性化电影中的潜力（和挑战），提供个人整个生命过程中 ASCVD 风险状态的动态读数。
Atherosclerotic cardiovascular disease (ASCVD) proceeds through a series of stages: initiation, progression (or regression), and complications. By integrating known biology regarding molecular signatures of each stage with recent advances in high-dimensional molecular data acquisition platforms (to assay the genome, epigenome, transcriptome, proteome, metabolome, and gut microbiome), “snapshots” of each phase of ASCVD development can be captured. In this review, we will summarize emerging approaches for assessment of ASCVD disease risk in humans using peripheral blood molecular signatures and molecular imaging approaches. We will then discuss the potential (and challenges) for these snapshots to be integrated into a personalized movie providing dynamic readouts of an individual’s ASCVD risk status throughout the life course.