Palladium-Catalyzed Coupling of Hydroxylamines with Aryl Bromides, Chlorides, and Iodides
Palladium-Catalyzed Coupling of Hydroxylamines with Aryl Bromides, Chlorides, and Iodides
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DOI：
10.1021/ol8025022
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发表时间：
2009-01-01
期刊：
影响因子：
5.2
通讯作者：
Tomkinson, Nicholas C. O.
中科院分区：
文献类型：
--
作者：
Porzelle, Achim;Woodrow, Michael D.;Tomkinson, Nicholas C. O.
双吡唑膦配体BippyPhos对钯催化的羟胺与芳基溴化物、氯化物和碘化物的交叉偶联反应是有效的。在80℃的甲苯中，在Cs2CO3存在下，反应顺利进行，以很好到很好的产率合成了用途广泛的N-芳基羟胺产品。
The bis-pyrazole phosphine ligand BippyPhos is effective for the palladium-catalyzed cross-coupling of hydroxylamines with aryl bromides, chlorides, and iodides. Reactions proceed smoothly at 80 degrees C in toluene in the presence Of Cs2CO3 to give synthetically versatile N-arylhydroxylamine products In good to excellent yield.