Syringic acid delivered via mPEG-PLGA-PLL nanoparticles enhances peripheral nerve regeneration effect
Syringic acid delivered via mPEG-PLGA-PLL nanoparticles enhances peripheral nerve regeneration effect
复制标题
通过 mPEG-PLGA-PLL 纳米粒子传递的丁香酸增强周围神经再生效果
DOI：
10.2217/nnm-2020-0042
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发表时间：
2020-06-01
期刊：
影响因子：
5.5
通讯作者：
Lin, Haodong
中科院分区：
文献类型：
--
作者：
Lin, Yaofa;Yu, Ronghua;Lin, Haodong
目的：研究黄芩酸（SA）的纳米载体及其功能增强。通过体外和体内试验对SA-PEAL的表征、贮存稳定性、药物释放、血液相容性和生物相容性进行了研究。结果：SA-PEAL具有良好的贮存稳定性、血液相容性和生物相容性，并能缓慢释放SA。结论：本研究为增强SA的神经修复功能提供了一种有效的纳米给药系统，促进了SA的进一步应用。
Aim:To deliver syringic acid (SA) with a nanocarrier and enhance its function.Materials & methods:mPEG-PLGA-PLL (PEAL) nanoparticles were used to deliver SA. The characterization, storage stability, drug release, blood-compatibility and biocompatibility of SA-PEAL were detected byin vitroandin vivoassays. Cellular phenotypic experiments and rat sciatic nerve injury models were used to evaluate the function of SA-PEALs.Results:SA-PEAL had good storage stability, blood-compatibility and biocompatibility and could slowly release SA. SA-PEAL significantly enhanced the proliferation and migration ability of Schwann cells and function recovery of injured sciatic nerves.Conclusion:Our study provides an effective nano-delivery system for enhancing the neural repair function of SA and promoting further applications of SA.