Evidence of non-random X chromosome activity in the mouse.
Evidence of non-random X chromosome activity in the mouse.
复制标题
小鼠非随机 X 染色体活性的证据。
DOI：
--
复制
发表时间：
1972
期刊：
影响因子：
--
通讯作者：
C. E. Williams
中科院分区：
文献类型：
--
作者：
B. Cattanach;C. E. Williams
在几种近交系小鼠的X染色体中检测到X连锁基因杂合表型的X连锁修饰。这种效应类似于在T（1; X）Ct X染色体中鉴定的X染色体控制元件Xce的替代“状态”或等位基因的效应。对两个这样不同的X染色体的试验表明，表型修饰要么是由于两个X染色体的非随机失活，要么是由于对通过X失活而分化的两个细胞群进行选择。这些数据提供了雌性小鼠体细胞中非随机X染色体活性的证据。
X-linked modification of the heterozygous phenotypes of X-linked genes has been detected in the X chromosomes of several inbred strains of mice. The effect is similar to that of the alternative ‘states’ or alleles, of the X chromosome controlling element, Xce , identified in T(1; X)Ct X chromosomes. Tests on two such differing X chromosomes have indicated that the phenotypic modification results either from non-random inactivation of the two X chromosomes or from selection operating on the two cell populations differentiated by X-inactivation. The data provide evidence of non-random X chromosome activity in the somatic cells of the female mouse.