Cytonuclear integration and co-evolution.
Cytonuclear integration and co-evolution.
复制标题
细胞核整合和共同进化。
DOI：
10.1038/s41576-018-0035-9
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发表时间：
2018-10
期刊：
影响因子：
--
通讯作者：
Havird JC
中科院分区：
文献类型：
--
作者：
Sloan DB;Warren JM;Williams AM;Wu Z;Abdel-Ghany SE;Chicco AJ;Havird JC
真核细胞内遗传物质在细胞核和细胞质（即线粒体和质体）基因组之间的分配需要这些基因组区室之间的协调整合，具有重要的进化和生物医学意义。经典的问题仍然存在，即通过基因丢失、转移和功能替换的结合，细胞质基因组普遍减少，但为什么它们几乎总是以某种最小的形式保留。细胞核整合的一个显着后果是存在由两个不同基因组编码的亚基组成的“嵌合”酶复合物。结构生物学和比较基因组学的进步正在对此类复合物的进化产生重要的见解，包括相关序列的变化和新亚基的招募。因此，嵌合细胞核复合物为了解分子共同进化机制提供了一个强有力的窗口。真核细胞不仅必须调节其核基因组，还必须调节与细胞器基因组（例如线粒体和质体）的密切功能相互作用。这篇综述讨论了细胞基因组在细胞核和细胞器之间划分的功能和进化意义，包括基因和基因产物的易位、嵌合酶复合物以及对分子协同进化的见解。
The partitioning of genetic material between the nucleus and cytoplasmic (i.e., mitochondrial and plastid) genomes within eukaryotic cells necessitates coordinated integration between these genomic compartments, with important evolutionary and biomedical implications. Classic questions persist about the pervasive reduction of cytoplasmic genomes via a combination of gene loss, transfer, and functional replacement — and yet why they are almost always retained in some minimal form. One striking consequence of cytonuclear integration is the existence of ‘chimeric’ enzyme complexes composed of subunits encoded in two different genomes. Advances in structural biology and comparative genomics are yielding important insights into the evolution of such complexes, including correlated sequence changes and recruitment of novel subunits. Thus, chimeric cytonuclear complexes provide a powerful window into the mechanisms of molecular coevolution. Eukaryotic cells must regulate not just their nuclear genomes, but also the intimate functional interplay with organelle genomes, such as in mitochondria and plastids. This Review discusses the functional and evolutionary implications of cellular genomes being partitioned between the nucleus and organelles, including the translocation of genes and gene products, chimeric enzyme complexes, and insights into molecular coevolution.
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影响因子：
3.3
作者：
Burger G;Gray MW;Forget L;Lang BF
通讯作者：
Lang BF
影响因子：
4.5
作者：
Chinnery PF;Craven L;Mitalipov S;Stewart JB;Herbert M;Turnbull DM
通讯作者：
Turnbull DM
DOI：
10.1073/pnas.171286998
发表时间：
2001-07-31
影响因子：
11.1
作者：
Amikura, R;Kashikawa, M;Kobayashi, S
通讯作者：
Kobayashi, S
影响因子：
2.5
作者：
Barbrook, Adrian C.;Voolstra, Christian R.;Howe, Christopher J.
通讯作者：
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影响因子：
10.7
作者：
Christie, Joshua R.;Beekman, Madeleine
通讯作者：
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