Intrahippocampal Scopolamine Impairs Both Acquisition and Consolidation of Contextual Fear Conditioning
Intrahippocampal Scopolamine Impairs Both Acquisition and Consolidation of Contextual Fear Conditioning
复制标题
DOI：
10.1006/nlme.2001.4005
复制
发表时间：
2001-05
影响因子：
2.7
通讯作者：
G. V. Wallenstein;David R. Vago
中科院分区：
文献类型：
--
作者：
G. V. Wallenstein;David R. Vago
背侧海马体的损伤已被证明会破坏与背景恐惧（对条件反射位置的恐惧）相关的记忆的获得和巩固，但不会影响对离散线索的恐惧条件反射（例如，音调）。阻断中枢毒蕈碱胆碱能受体的激活导致选择性习得情境恐惧条件反射的缺陷，但据报道对巩固效果甚微。在这里，我们首次表明，直接输注的毒蕈碱胆碱能受体拮抗剂，东莨菪碱，到背侧海马产生剂量依赖性赤字的收购和巩固的上下文恐惧条件反射，而没有影响简单的音调条件反射。
Lesions of the dorsal hippocampus have been shown to disrupt both the acquisition and the consolidation of memories associated with contextual fear (fear of the place of conditioning), but do not affect fear conditioning to discrete cues (e.g., a tone). Blockade of central muscarinic cholinergic receptor activation results in selective acquisition deficits of contextual fear conditioning, but reportedly has little effect on consolidation. Here we show for the first time that direct infusion of the muscarinic cholinergic receptor antagonist, scopolamine, into the dorsal hippocampus produces a dose-dependent deficit in both acquisition and consolidation of contextual fear conditioning, while having no impact on simple tone conditioning.