Evaluation of peripheral serotonin content and 2-adrenergic receptor function as potential markers for life-long recurrent depressive disorder by using methodological improvements
Evaluation of peripheral serotonin content and 2-adrenergic receptor function as potential markers for life-long recurrent depressive disorder by using methodological improvements
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DOI：
10.1080/13651501.2017.1411516
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发表时间：
2018-01-01
影响因子：
3
通讯作者：
Gjorgoski, Icko
中科院分区：
文献类型：
--
作者：
Aleksovski, Boris;Novotni, Antoni;Gjorgoski, Icko
目的：目的：探讨外周血血小板5-羟色胺含量、血浆5-羟色胺浓度及血小板（2）-肾上腺素能受体（2-AR）功能作为复发性抑郁障碍（RDD）状态或特质生物标志物的作用及相关性。结果：RDD患者血小板5-羟色胺含量降低，血浆5-羟色胺浓度升高，血小板（2）-AR脱敏。变量被发现异质性，主要受当前发作的临床特征。高振幅的（2）-AR与严重的焦虑症状和高血小板5-羟色胺含量（以及低血浆5-羟色胺水平）与精神病性symptoms.Conclusions：评估的外周标志物反映只有状态（但不是特质）异常的患者目前严重发作的RDD。观察到的外周（2）-AR和5-羟色胺异常相互不相关，它们可能由不同的机制触发。
Objective: We aimed to evaluate the role and the relations between peripheral platelet serotonin content, blood plasma serotonin concentration and the function of platelet (2)-adrenergic receptors ((2)-AR) as potential state or trait biomarkers for recurrent depressive disorder (RDD).Methods: 26 drug-free patients with life-long RDD and 31 healthy controls were included in the study. Several methodological improvements in blood collection and platelet isolation were implemented following the present standards in Haematology and Light transmission aggregometry.Results: Our results have shown lower platelet serotonin content, higher plasma serotonin concentration and desensitization of platelet (2)-AR in patients with RDD. The variables were found heterogeneous and mainly influenced by the clinical characteristics of the current episode. High amplitude of the (2)-AR correlated with severe anxious symptoms and high platelet serotonin content (as well as low plasma serotonin levels) were associated with psychotic symptoms.Conclusions: The evaluated peripheral markers reflect only state (but not trait) abnormalities in patients with current severe episode of RDD. The observed peripheral (2)-AR and serotonin abnormalities are mutually not related and they are probably triggered by different mechanisms.