Relationship between free-living daily physical activity and peripheral circulation in patients with intermittent claudication
Relationship between free-living daily physical activity and peripheral circulation in patients with intermittent claudication
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DOI：
10.1177/000331979905000404
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发表时间：
1999-04-01
期刊：
影响因子：
2.8
通讯作者：
Fonong, T
中科院分区：
文献类型：
--
作者：
Gardner, AW;Killewich, LA;Fonong, T
本研究的目的是确定外周动脉闭塞性疾病（PAOD）间歇性跛行患者在静息、反应性充血和最大运动条件下自由生活的日常体力活动与外周循环之间的关系。从巴尔的摩退伍军人事务医疗中心血管诊所和广播和报纸广告中招募61名pad患者（年龄=70 +/-6岁，踝/肱指数[ABI] =0.57 +/-0.24）。自由生活的日常体力活动被测量为体力活动的能量消耗（EEPA），由双标记水和间接量热法测定。患者的踝/肱指数、小腿血流、小腿经皮氧张力（TcPO2）和小腿经皮加热功率（TcHP）也被表征。ABI和小腿血流作为下肢大循环指标，TcPO2和TcHP作为微循环指标。跛行患者久坐不动，平均EEPA值为486 +/-274 kcal/天。EEPA与犊牛静止时（282 +/-24 mW; r=-0.413, p=0.002）、术后反应性充血后（275 +/-22 mW; r=-0.381, p=0.004）和最大运动后（276 +/-20 mW; r=-0.461, p=0.002）的TcHP相关
The purpose of this study was to determine the relationship between free-living daily physical activity and peripheral circulation under resting, reactive hyperemia, and maximal exercise conditions in peripheral arterial occlusive disease (PAOD) patients with intermittent claudication. Sixty-one PAOD patients (age=70 +/-6 years, ankle/brachial index [ABI] =0.57 +/-0.24) were recruited from the Vascular Clinic at the Baltimore Veterans Affairs Medical Center and from radio and newspaper advertisements. Free-living daily physical activity was measured as the energy expenditure of physical activity (EEPA), determined from doubly labeled water and indirect calorimetry. Patients also were characterized on ankle/brachial index, calf blood flow, calf transcutaneous oxygen tension (TcPO2), and calf transcutaneous heating power (TcHP). ABI and calf blood flow served as markers of the macrocirculation of the lower extremity, while TcPO2 and TcHP served as markers of the microcirculation. The claudication patients were sedentary, reflected by a mean EEPA value of 486 +/-274 kcal/day. EEPA was related to calf TcHP at rest (282 +/-24 mW; r=-0.413, p=0.002), after postocclusion reactive hyperemia (275 +/-22 mW; r=-0.381, p=0.004), and after maximal exercise (276 +/-20 mW; r=-0.461, p