Late treatment-related morbidity in breast cancer patients randomized to postmastectomy radiotherapy and systemic treatment versus systemic treatment alone
Late treatment-related morbidity in breast cancer patients randomized to postmastectomy radiotherapy and systemic treatment versus systemic treatment alone
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DOI：
10.1080/028418600750013131
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发表时间：
2000-01-01
期刊：
影响因子：
3.1
通讯作者：
Overgaard, J
中科院分区：
文献类型：
--
作者：
Hojris, I;Andersen, J;Overgaard, J
在丹麦乳腺癌合作组试验82 b和c中随机分组的84例患者中，评估了乳房切除术和辅助全身治疗（有或无术后放疗）后的晚期治疗相关发病率。采用基于迟发效应正常组织（LENT）评分系统构建的标准化评估表进行结构化访谈和体格检查。乳房切除术后的中位随访时间为9年（范围6-13年）。在14%的放射治疗患者中测量到淋巴水肿，而在3%的非放射治疗患者（NS）中测量到淋巴水肿。在45%的接受过放射治疗的女性中测量到肩部发病率略有下降，而在15%的未接受过放射治疗的患者中测量到肩部发病率略有下降，但是在仅5%的接受过放射治疗的患者中观察到中度或更严重的损伤，而在未接受过放射治疗的患者中没有观察到中度或更严重的损伤（p = 0.004）。17%的放射治疗患者和2%的非放射治疗患者发现肩部运动障碍引起症状（p = 0.001）。
Late treatment-related morbidity after mastectomy and adjuvant systemic treatment with and without postoperative irradiation was assessed in 84 patients randomized in the Danish Breast Cancer Cooperative Group Trials 82b and c. A structured interview and physical examination, using a standardized assessment sheet, constructed on the basis of the late effects normal tissues (LENT) scoring system, was used. The median length of follow-up from mastectomy was 9 years (range 6-13 years). Lymphedema was measured in 14% of the irradiated patients versus 3% of the non-irradiated patients (NS). Slightly decreased shoulder morbidity was measured in 45% of the irradiated women versus 15% of the non-irradiated patients, but moderate or more severe impairment was seen in only 5% of the irradiated patients and in none of the non-irradiated patients (p = 0.004). Seventeen percent of the irradiated patients and 2% of the non-irradiated patients found that impairment of shoulder movement caused symptoms (p = 0.001).