Bone Tissue Engineering.
Bone Tissue Engineering.
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DOI：
10.1007/s40610-015-0022-2
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发表时间：
2015
期刊：
影响因子：
--
通讯作者：
Oreffo RO
中科院分区：
文献类型：
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作者：
Black CR;Goriainov V;Gibbs D;Kanczler J;Tare RS;Oreffo RO
医学进步带来了可喜的预期寿命延长。然而，伴随而来的长寿带来了新的挑战：与年龄相关的疾病增加，生活质量相应降低。伴随着创伤、损伤、疾病或老年的骨骼组织的丧失可能导致严重的发病率和重大的社会经济代价，并强调需要新的、更可靠的骨骼再生战略。为了解决未得到满足的骨增强需求，近年来，组织工程学和再生医学随着新的骨组织形成方法的出现而脱颖而出。通常，这些方法寻求利用干细胞、创新的支架和生物因素，承诺增强和更可靠的骨形成策略，以改善许多人的生活质量。本文综述了骨组织工程在骨干细胞、血管发育、骨形成以及从临床前体内模型向临床模型的转化等方面的最新进展。
Medical advances have led to a welcome increase in life expectancy. However, accompanying longevity introduces new challenges: increases in age-related diseases and associated reductions in quality of life. The loss of skeletal tissue that can accompany trauma, injury, disease or advancing years can result in significant morbidity and significant socio-economic cost and emphasise the need for new, more reliable skeletal regeneration strategies. To address the unmet need for bone augmentation, tissue engineering and regenerative medicine have come to the fore in recent years with new approaches for de novo skeletal tissue formation. Typically, these approaches seek to harness stem cells, innovative scaffolds and biological factors that promise enhanced and more reliable bone formation strategies to improve the quality of life for many. This review provides an overview of recent developments in bone tissue engineering focusing on skeletal stem cells, vascular development, bone formation and the translation from preclinical in vivo models to clinical delivery.