SEQUELAE OF VENEZUELAN EQUINE ENCEPHALITIS IN HUMANS - 4 YEAR FOLLOW-UP
SEQUELAE OF VENEZUELAN EQUINE ENCEPHALITIS IN HUMANS - 4 YEAR FOLLOW-UP
复制标题
DOI：
10.1093/ije/4.2.131
复制
发表时间：
1975-01-01
影响因子：
7.7
通讯作者：
DEGUZMAN, R
中科院分区：
文献类型：
--
作者：
LEON, CA;JARAMILLO, R;DEGUZMAN, R
本研究的目的是鉴定感染委内瑞拉马脑炎病毒（VEE）的人类个体可能的后遗症。特别强调探索神经、心理和行为方面的问题，特别是寻找这种疾病与癫痫现象、脑损伤和/或智力缺陷之间的可能联系。对1967年发生VEE流行的哥伦比亚El Carmelo的儿童样本进行了为期四年的观察。表现为脑病型并因中枢神经系统受累症状住院并确诊为VEE的7名儿童构成指标组。这组儿童与四个人口统计学特征相匹配的对照组进行比较，但根据他们在流行时是否生病以及他们是否有感染VEE病毒的血清学证据进行区分。在随访期间的三个时间点进行了评估，其中包括以下程序：(1)对个人背景和行为进行调查（通过处理所有功能领域的标准问卷）；(2)全面的儿科检查，包括仔细的神经系统检查；(3)利用智力测验进行心理检查；(4)在患者清醒、睡眠和光刺激下，按标准技术进行脑电图检查；(5)每两周一次家访，记录观察期间的并发疾病情况。统计分析结果显示，两组间异常分布差异显著。
The purpose of this study was the identification of possible sequelae of the infection of human individuals with Virus of Venezuelan Equine Encephalitis (VEE). Special emphasis was laid on exploring neurological, psychological and behavioural aspects and particularly on the search for a possible association of the disease with epileptic phenomena, brain damage and/or mental deficiency.A four-year period of observation was conducted on a sample of children from El Carmelo (Colombia) where an epidemic of VEE took place in 1967. A group of seven children who presented the encephalitic type of the illness and were hospitalized with symptoms of CNS involvement and a confirmed diagnosis of VEE constituted the index group. This group was compared with four control groups of children with matched demographic characteristics but separated according to whether they were ill at the time of the epidemic and whether they presented serological evidence of having been infected with VEE Virus.Evaluations were conducted at three points in time during the follow-up period and they included the following procedures: (1) Survey on personal background and behaviour (through a standard questionnaire dealing with all areas of functioning); (2) Complete paediatric examination, including a careful neurological check-up; (3) Psychological examination using intelligence tests; (4) Electro-encephalographic examination according to standard techniques, with the patient awake, asleep and under photic stimulation; (5) Bi-weekly home visits to keep a record on intercurrent illness throughout the observation period. Statistical analysis of results shows significant differences between the groups in regard to the distribution of abnormalities.