Glucagon test for insulinoma: a chemical study in 25 cases
Glucagon test for insulinoma: a chemical study in 25 cases
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胰高血糖素检测胰岛素瘤：25 例化学研究
DOI：
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发表时间：
1968
影响因子：
3.4
通讯作者：
E. Samols
中科院分区：
文献类型：
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作者：
V. Marks;E. Samols
在13名胰岛素瘤患者和33名正常对照者中测定了对1 mg肌内注射胰高血糖素的毛细血管血糖反应;胰岛素瘤患者显示出正常的初始升高，但随后出现异常大的下降，在每种情况下在90至180分钟之间达到低血糖水平。在14例胰岛素瘤患者静脉血糖和血浆胰岛素对1 mg静脉注射胰高血糖素的反应与10例正常对照进行了比较; 14例患者中有10例血浆胰岛素异常大幅升高，大多数患者的静脉血糖在整个试验过程中低于正常水平。在这14例患者的血浆胰岛素反应后，口服和静脉注射葡萄糖，口服亮氨酸后，静脉注射甲苯磺丁脲，这些测试在胰岛素瘤的识别和鉴别诊断的价值进行了比较，与静脉胰高血糖素试验。
The capillary blood glucose response to lmg of intramuscular glucagon was determined in 13 patients with insulinoma and in 33 normal controls; the insulinoma patients showed a normal initial rise, but this was followed by an abnormally large fall, reaching hypoglycaemic levels between 90 and 180 minutes in every case. In 14 insulinoma patients the response of venous blood glucose and also plasma insulin to lmg of intravenous glucagon was compared with 10 normal controls; there was an abnormally large rise of plasma insulin in 10 of the 14 patients, and in the majority the venous blood glucose was below normal throughout the test. In these 14 patients the plasma insulin response was also determined after oral and intravenous glucose, after oral leucine, and after intravenous tolbutamide, and the value of these tests in the recognition and differential diagnosis of insulinoma was compared with that of the intravenous glucagon test.