The activating immunoreceptor NKG2D and its Ligands are involved in, allograft transplant rejection
The activating immunoreceptor NKG2D and its Ligands are involved in, allograft transplant rejection
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DOI：
10.4049/jimmunol.179.10.6416
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发表时间：
2007-11-15
影响因子：
4.4
通讯作者：
Kang, Sang-Mo
中科院分区：
文献类型：
--
作者：
Kim, Jim;Chang, Catherine K.;Kang, Sang-Mo
虽然先天免疫和获得性免疫在移植中的联系已被公认，但这种合作的机制仍有待充分阐明。在这项研究中，我们发现，早期的“危险”信号与移植导致NKG2D配体的快速上调。第二波NKG 2D配体上调是由对同种异体移植物的适应性免疫反应介导的。抗NKG2D抗体治疗在预防心脏同种异体移植物的CD28非依赖性排斥反应方面非常有效。值得注意的是，NKG2D阻断不会耗尽CD8（+）T细胞或NK1.1（+）细胞，也不会影响它们向同种异体移植物的迁移。这些结果确立了NKG2D及其配体在实体器官移植排斥反应中的功能作用。
Although the linkage between innate and adaptive immunity in transplantation has been recognized, the mechanisms underlying this cooperation remain to be fully elucidated. In this study, we show that early "danger" signals associated with transplantation lead to rapid up-regulation of NKG2D ligands. A second wave of NKG2D ligand up-regulation is mediated by the adaptive immune response to allografts. Treatment with an Ab to NKG2D was highly effective in preventing CD28-independent rejection of cardiac allografts. Notably, NKG2D blockade did not deplete CD8(+) T cells or NK1.1(+) cells nor affect their migration to the allografts. These results establish a functional role of NKG2D and its ligands in the rejection of solid organ transplants.