Modifications of bone material properties in postmenopausal osteoporotic women long-term treated with alendronate
Modifications of bone material properties in postmenopausal osteoporotic women long-term treated with alendronate
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DOI：
10.1530/eje-11-0333
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发表时间：
2011-10-01
影响因子：
5.8
通讯作者：
Boivin, Georges
中科院分区：
文献类型：
--
作者：
Bala, Yohann;Farlay, Delphine;Boivin, Georges
目的：考虑到近年来对双膦酸盐（BP）治疗长期安全性的关注，研究长期阿仑膦酸盐（ALN）治疗对绝经后骨质疏松症（PMOP）妇女内在骨特性的影响。设计和方法：对32名门诊接受口服ALN治疗6.4 +/- 2.0年的PMOP妇女进行经髂骨活检。反映骨矿化的变量在组织水平上用定量显微放射学和晶体水平上用傅里叶变换红外显微光谱测量。采用维氏压痕试验研究骨显微硬度。结果比较了22名年龄匹配的未经治疗的PMOP妇女。结果：ALN的长期治疗与84% (P
Objective: Given recent concern about long-term safety of bisphosphonate (BP) therapy, the effects of long-term alendronate (ALN) therapy on intrinsic bone properties were studied among postmenopausal osteoporotic (PMOP) women.Design and methods: Transiliac bone biopsies were obtained from 32 outpatient clinic PMOP women treated with oral ALN for 6.4 +/- 2.0 years. Variables reflecting bone mineralization were measured both at tissue level using quantitative microradiography and at crystal level by Fourier transform infrared microspectroscopy. Bone microhardness was investigated by Vickers indentation tests. Results were compared with those from 22 age-matched untreated PMOP women.Results: Long-term treatment with ALN was associated with a 84% (P