In vivo electrical conductivity of hepatic tumours
In vivo electrical conductivity of hepatic tumours
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DOI：
10.1088/0967-3334/24/2/302
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发表时间：
2003-05-01
影响因子：
3.2
通讯作者：
Webster, JG
中科院分区：
文献类型：
--
作者：
Haemmerich, D;Staelin, ST;Webster, JG
组织电导率的知识对于确定电磁能量的沉积是必要的，并且可以进一步用于诊断区分正常组织和肿瘤组织。我们测量了17只大鼠，共24个肿瘤的K12/TRb大鼠结肠癌细胞系。在每只动物中，我们在诱导后6至12周的不同肿瘤阶段，在10 Hz至1 MHz的7个频率下测量了体内肝肿瘤和正常组织的电导率。正常肝组织的电导率在10 Hz时为1.26 +/- 0.15 mS cm（-1），在1 MHz时为4.61 +/- 0.42 mS cm（-1）。肿瘤的电导率在10 Hz时为2.69 +/- 0.91 mS cm（-1），在1 MHz时为5.23 +/- 0.82 mS cm（-1）。正常组织和肿瘤组织的电导率有显著性差异（p < 0.05）。我们确定了测量部位坏死和纤维化的百分比。我们将电导率数据拟合到Cole-Cole模型。对于肿瘤数据，我们确定了Cole-Cole参数与年龄、坏死、纤维化和肿瘤体积之间的斯皮尔曼相关系数，发现坏死与Cole-Cole参数之间存在显著相关性（p < 0.05）。我们的结论是，肿瘤内的坏死和相关的膜破裂可能是负责观察到的电导率的变化。
Knowledge of electrical tissue conductivity is necessary to determine deposition of electromagnetic energy and can further be used to diagnostically differentiate between normal and neoplastic tissue. We measured 17 rats with a total of 24 tumours of the K12/TRb rat colon cancer cell line. In each animal we measured in vivo hepatic tumour and normal tissue conductivity at seven frequencies from 10 Hz to 1 MHz, at different tumour stages between 6 and 12 weeks after induction. Conductivity of normal liver tissue was 1.26 +/- 0.15 mS cm(-1) at 10 Hz, and 4.61 +/- 0.42 mS cm(-1) at 1 MHz. Conductivity of tumour was 2.69 +/- 0.91 mS cm(-1) at 10 Hz, and 5.23 +/- 0.82 mS cm(-1) at I MHz. Conductivity was significantly different between normal and tumour tissue (p < 0.05). We determined the percentage of necrosis and fibrosis at the measurement site. We fitted the conductivity data to the Cole-Cole model. For the tumour data we determined Spearman's correlation coefficients between the Cole-Cole parameters and age, necrosis, fibrosis and tumour volume and found significant correlation between necrosis and the Cole-Cole parameters (p < 0.05). We conclude that necrosis within the tumour and the associated membrane breakdown is likely responsible for the observed change in conductivity.