Duality of B Cell-CXCL13 Axis in Tumor Immunology.
Duality of B Cell-CXCL13 Axis in Tumor Immunology.
复制标题
肿瘤免疫学中B细胞CXCL13轴的双重性。
DOI：
10.3389/fimmu.2020.521110
复制
发表时间：
2020
影响因子：
7.3
通讯作者：
Zhong X
中科院分区：
文献类型：
--
作者：
Rubio AJ;Porter T;Zhong X
肿瘤免疫是一个快速发展的研究领域，由依赖于细胞类型、肿瘤类型和肿瘤进展阶段的免疫细胞肿瘤相互作用的许多可能排列组成。同时，大多数癌症免疫疗法集中于调节T细胞介导的抗肿瘤免疫应答，并且在很大程度上忽略了B细胞在肿瘤免疫方面所具有的潜在效用。因此，这激发了对B细胞及其伴随的趋化因子CXCL 13在多种肿瘤类型的肿瘤免疫中所起作用的探索。B细胞和CXCL 13对肿瘤的进展和肿瘤免疫具有双重作用，本文将对此进行详细的综述。具体而言，各种B细胞亚型能够抑制或增强几种重要的免疫功能。有趣的是，CXCL 13已被证明在多种肿瘤类型中驱动几种促生长和侵入性信号传导途径，同时还与其他肿瘤类型中改善的存活率和免疫细胞肿瘤定位相关。还讨论了更好地阐明B细胞和CXCL 13影响抗肿瘤免疫应答的机制的潜在工具。此外，提出了多种策略来调节用于癌症免疫治疗的B细胞-CXCL 13轴。
Tumor immunity is a rapidly evolving area of research consisting of many possible permutations of immune cell tumor interactions that are dependent upon cell type, tumor type, and stage in tumor progression. At the same time, the majority of cancer immunotherapies have been focused on modulating the T cell-mediated antitumor immune response and have largely ignored the potential utility that B cells possess with respect to tumor immunity. Therefore, this motivated an exploration into the role that B cells and their accompanying chemokine, CXCL13, play in tumor immunity across multiple tumor types. Both B cells and CXCL13 possess dualistic impacts on tumor progression and tumor immunity which is furthered detail in this review. Specifically, various B cells subtypes are able to suppress or enhance several important immunological functions. Paradoxically, CXCL13 has been shown to drive several pro-growth and invasive signaling pathways across multiple tumor types, while also, correlating with improved survival and immune cell tumor localization in other tumor types. Potential tools for better elucidating the mechanisms by which B cells and CXCL13 impact the antitumor immune response are also discussed. In addition, multiples strategies are proposed for modulating the B cell-CXCL13 axis for cancer immunotherapies.
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影响因子：
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作者：
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影响因子：
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DOI：
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发表时间：
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期刊：
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影响因子：
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作者：
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