Nuclear DNA Content Varies with Cell Size across Human Cell Types
Nuclear DNA Content Varies with Cell Size across Human Cell Types
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DOI：
10.1101/cshperspect.a019091
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发表时间：
2015-07-01
影响因子：
7.2
通讯作者：
Damiani, Rachel
中科院分区：
文献类型：
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作者：
Gillooly, James F.;Hein, Andrew;Damiani, Rachel
细胞大小的变化，以及它们所包含的DNA，是多细胞生物的一个基本特征，影响着它们结构和功能的无数方面。众所周知，在人类体内，细胞大小有几个数量级的差异，并且经常观察到细胞之间核DNA含量的差异。使用已发表的数据，我们在这里描述了19种不同人类细胞类型的核DNA数量如何随着细胞体积的增加而增加。这种观察到的增加是类似的种内关系DNA含量和细胞体积在其他物种，二倍体基因组大小和细胞体积之间的种间关系。因此，我们推测，人类体细胞核DNA含量的数量可能最好被视为反映细胞大小分布的值的分布，而不是作为一个单一的，不可变的量。
Variation in the size of cells, and the DNA they contain, is a basic feature of multicellular organisms that affects countless aspects of their structure and function. Within humans, cell size is known to vary by several orders of magnitude, and differences in nuclear DNA content among cells have been frequently observed. Using published data, here we describe how the quantity of nuclear DNA across 19 different human cell types increases with cell volume. This observed increase is similar to intraspecific relationships between DNA content and cell volume in other species, and interspecific relationships between diploid genome size and cell volume. Thus, we speculate that the quantity of nuclear DNA content in somatic cells of humans is perhaps best viewed as a distribution of values that reflects cell size distributions, rather than as a single, immutable quantity.