Admixture mapping for hypertension loci with genome-scan markers
Admixture mapping for hypertension loci with genome-scan markers
复制标题
利用基因组扫描标记绘制高血压基因座的混杂图谱
DOI：
10.1038/ng1510
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发表时间：
2005-02-01
期刊：
影响因子：
30.8
通讯作者：
Weder, A
中科院分区：
文献类型：
--
作者：
Zhu, XF;Luke, A;Weder, A
鉴定导致高血压风险的遗传变异具有挑战性。作为对连锁和候选基因关联研究的补充，我们在美国国家心脏、肺和血液研究所家庭血压项目的非裔美国人参与者中使用基因组扫描微卫星标记进行了混合物作图。这一人群被认为经历了来自非洲和欧洲的祖先群体的最近混合。我们使用一组来自尼日利亚的无关个体来代表非洲祖先人群，并使用家庭血压计划中的欧洲裔美国人来提供欧洲祖先等位基因频率的估计值。我们在同一实验室的三组中对一组共有的269个微卫星标记进行了基因分型。多点分析的基础上，标记位置特定的非洲血统的分布，在高血压病例与血压正常的对照组向上移动，与易感基因的连锁一致。这种变化主要是由于少数位点，包括染色体6q上的五个相邻标记和染色体21q上的两个标记。这些结果表明，染色体6q24和21q21可能含有影响非洲裔美国人高血压风险的基因。
Identification of genetic variants that contribute to risk of hypertension is challenging. As a complement to linkage and candidate gene association studies, we carried out admixture mapping using genome-scan microsatellite markers among the African American participants in the US National Heart, Lung, and Blood Institute's Family Blood Pressure Program. This population was assumed to have experienced recent admixture from ancestral groups originating in Africa and Europe. We used a set of unrelated individuals from Nigeria to represent the African ancestral population and used the European Americans in the Family Blood Pressure Program to provide estimates of allele frequencies for the European ancestors. We genotyped a common set of 269 microsatellite markers in the three groups at the same laboratory. The distribution of marker location-specific African ancestry, based on multipoint analysis, was shifted upward in hypertensive cases versus normotensive controls, consistent with linkage to genes conferring susceptibility. This shift was largely due to a small number of loci, including five adjacent markers on chromosome 6q and two on chromosome 21q. These results suggest that chromosome 6q24 and 21q21 may contain genes influencing risk of hypertension in African Americans.