A ruthenium-grafted hydrotalcite as a multifunctional catalyst for direct α-alkylation of nitriles with primary alcohols
A ruthenium-grafted hydrotalcite as a multifunctional catalyst for direct α-alkylation of nitriles with primary alcohols
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DOI：
10.1021/ja049181l
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发表时间：
2004-05-12
影响因子：
15
通讯作者：
Kaneda, K
中科院分区：
文献类型：
--
作者：
Motokura, K;Nishimura, D;Kaneda, K
水滑石用RuCl3·nH2O水溶液处理后，表面形成单体Ru(IV)物种。这种新型的Ru接枝水滑石(Ru/HT)通过Ru物种与表面碱位之间的协同催化，有效地催化了腈与伯醇的α烷基化反应。通过碱催化的α，α-烷基苯乙腈与活性烯烃的迈克尔反应，该催化剂体系可进一步扩展到一锅法合成α-二烷基苯乙腈。
Treatment of a hydrotacite, Mg6Al2(OH)16CO3, with an aqueous solution of RuCl3·nH2O afforded a monomeric Ru(IV) species on the surface of the hydrotalcite. This novel Ru-grafted hydrotalcite (Ru/HT) efficiently catalyzed α-alkylation of nitriles with primary alcohols through the cooperative catalysis between the Ru species and the surface base sites. The catalyst system could be further extended for the one-pot synthesis of α,α-dialkylated phenylacetonitriles via the base-catalyzed Michael reaction of α-alkylated phenylacetonitrile with activate olefins.