NUCLEOTIDE-SEQUENCE OF THE AIDS VIRUS, LAV
NUCLEOTIDE-SEQUENCE OF THE AIDS VIRUS, LAV
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DOI：
10.1016/0092-8674(85)90303-4
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发表时间：
1985-01-01
期刊：
影响因子：
64.5
通讯作者：
ALIZON, M
中科院分区：
文献类型：
--
作者：
WAINHOBSON, S;SONIGO, P;ALIZON, M
确定了艾滋病（获得性免疫缺陷综合征）可能的病原体——淋巴结病相关病毒（LAV）的完整的9193个核苷酸序列。推导出来的基因结构是独特的：除了逆转录病毒的gag、pol和env基因外，它还显示出两个新的开放阅读框，称为Q和F。值得注意的是，Q位于pol和env之间，F有一半由长末端重复序列（LTR）的U3元件编码。这些数据表明LAV不同于先前已鉴定的人类T细胞白血病/淋巴瘤病毒家族。
The complete 9193-nucleotide sequence of the probable causative agent of AIDS [acquired immune deficiency syndrome], lymphadenopathy-associated virus (LAV), was determined. The deduced genetic structure is unique: it shows, in addition to the retroviral gag, pol and env genes, 2 novel open reading frames termed Q and F. Remarkably, Q is located between pol and env and F is half-encoded by the U3 element of the LTR [long terminal repeat]. The data place LAV apart from the previously characterized family of human T cell leukemia/lymphoma viruses.