HEMORRHAGE-INDUCED PRODUCTION OF FOS IN NEURONS OF THE LAMINA TERMINALIS - ROLE OF ENDOGENOUS ANGIOTENSIN-II
HEMORRHAGE-INDUCED PRODUCTION OF FOS IN NEURONS OF THE LAMINA TERMINALIS - ROLE OF ENDOGENOUS ANGIOTENSIN-II
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DOI：
10.1016/0304-3940(93)90821-2
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发表时间：
1993-09-03
影响因子：
2.5
通讯作者：
MCKINLEY, MJ
中科院分区：
文献类型：
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作者：
BADOER, E;OLDFIELD, BJ;MCKINLEY, MJ
低血压性出血增加了清醒大鼠穹窿下器（SFO）和终板血管器（OVLT）以及视上核（SON）和室旁核（PVN）细胞中Fos（细胞活化的标志物）的产生。用巯甲丙脯酸（100 mg/kg i. p.）抑制SFO和OVLT细胞中Fos的产生，但不降低PVN和SON中Fos阳性细胞核的浓度。结果表明，Fos的生产在SFO和OVLT出血引起的可能是由于循环血管紧张素II水平升高。
Hypotensive haemorrhage increased the production of Fos, a marker of cell activation, in cells of the subfornical organ (SFO) and the organum vasculosum of the lamina terminalis (OVLT) as well as in the supraoptic (SON) and paraventricular (PVN) nuclei in conscious rats. Pretreatment with captopril (100 mg/kg i.p.) inhibited the production of Fos in cells of the SFO and OVLT but did not reduce the concentration of Fos-positive cell nuclei in the PVN and SON. The results suggest that the production of Fos in the SFO and OVLT induced by the haemorrhage is probably due to elevated levels of circulating angiotensin II.