A clinical review of the association of thyroid stimulating hormone and cognitive impairment.
A clinical review of the association of thyroid stimulating hormone and cognitive impairment.
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DOI：
10.1155/2013/856017
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发表时间：
2013-09-23
期刊：
影响因子：
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通讯作者：
Lökk J
中科院分区：
文献类型：
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作者：
Annerbo S;Lökk J
临床和亚临床甲状腺功能减退症以及明显的甲状腺功能亢进症的中年和老年人都与认知功能下降，如记忆，反应时间，和视觉空间组织。亚临床甲状腺功能亢进症（SH）或低浓度的血清TSH浓度已与痴呆在以前的流行病学研究，但在老年人的关联尚未建立。关于甲状腺功能如何与老年人的认知能力相关，几乎没有共识。在这篇集中的综述中，我们对过去五年中的11项研究进行了检查，研究了老年人甲状腺功能与认知能力之间的关系，老年人在血清TSH和甲状腺激素浓度轻微异常的个体中比例过高。其中6项研究显示SH与认知障碍或痴呆之间存在一致的关联。总的来说，考虑到最大和最有力的设计研究，有一个强有力的证据支持SH和认知障碍之间的关联。关于这些主题的出版物数量稀少，表明需要更多的研究，特别是关于纵向和干预性研究，从而有望确认或拒绝TSH异常和痴呆之间的因果关系。
Clinical and subclinical hypothyroidism as well as overt hyperthyroidism in middle-aged and elderly adults are both associated with decreased cognitive functioning as memory, reaction time, and visuospatial organization. Subclinical hyperthyroidism (SH) or low serum concentrations of TSH concentrations have been associated with dementia in previous epidemiological studies, but the association in the elderly has not been established. There is little or no consensus regarding how thyroid function is associated with cognitive performance in the elderly. In this focused review, we have performed an examination between eleven studies from the last five years examining the association between thyroid function and cognitive performance in elderly people, a group who is overrepresented among individuals with minor abnormalities in serum TSH and thyroid hormone concentration. Six of the studies showed a consistent finding of an association between SH with cognitive impairment or dementia. In general, taking into account the largest and most powerfully designed studies, there is a strong body of evidence supporting the association between SH and cognitive impairment. The scarce number of publications on these topics indicates the need of more research especially regarding longitudinal and interventional studies thus hopefully enabling confirmation or rejection of causality between TSH abnormalities and dementia.